2-[(1E)-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-methylhydrazin-1-ylidene}methyl]-N,N'-bis(2-chlorophenyl)propanediamide CAS 306978-29-0
| CAS No. | 306978-29-0 |
| Molecular Formula | C23H17Cl3F3N5O2 |
| Molecular Weight | 558.77 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-[(1E)-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-methylhydrazin-1-ylidene}methyl]-N,N'-bis(2-chlorophenyl)propanediamide.
CATO supplies 2-[(1E)-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-methylhydrazin-1-ylidene}methyl]-N,N'-bis(2-chlorophenyl)propanediamide (CAS 306978-29-0), a certified reference material (molecular formula C23H17Cl3F3N5O2, MW 558.77 g/mol) for analytical method development and quality control.
The molecular framework of 2-[(1E)-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-methylhydrazin-1-ylidene}methyl]-N,N'-bis(2-chlorophenyl)propanediamide (C23H17Cl3F3N5O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H17Cl3F3N5O2 |
| Molecular Weight | 558.77 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related E Standards
- N-(6-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](methyl)amino}-2,5-dioxo-2H,5H,6H-pyrano[3,2-c]pyridin-3-yl)-3-(trifluoromethyl)benzamide (CAS 341966-33-4)
- N-(2-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-5-(trifluoromethyl)phenyl)-3-methoxybenzamide (CAS 478262-09-8)
- N-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-2-[(6-acetamidopyridin-3-yl)sulfanyl]benzamide (CAS 338962-76-8)
- [(1E)-3-(4-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}phenyl)-3-oxoprop-1-en-1-yl](methyl)amino 4-methylbenzoate (CAS 303151-66-8)
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- 4-Chloro-2-(3-chlorophenyl)-5-(4-(2,6-dinitro-4-(trifluoromethyl)phenyl)piperazin-1-yl)pyridazin-3(2H)-one (CAS 477867-41-7)
- Methyl 6-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-[(E)-({[(4-chlorophenyl)methoxy]amino}methylidene)amino]-4H,5H,6H,7H-thieno[2,3-c]pyridine-3-carboxylate (CAS 321430-40-4)
- 1-(5-Chloro-4-((8-methoxy-1-methyl-3-(2-(methylamino)-2-oxoethoxy)-2-oxo-1,2-dihydroquinolin-6-yl)amino)pyrimidin-2-yl)-N,N-dimethylpiperidine-4-carboxamide (CAS 2166387-64-8)
Recommended Standards
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- 2-[Bis[2,4,6-tris(1-methylethyl)phenyl]phosphino]benzoic acid (CAS 2407524-96-1)
- 1,4-Bis((2,6-diisopropylphenyl)amino)anthracene-9,10-dione (CAS 41578-10-3)
- Dronedarone Impurity 17 (CAS CATO-C4X-109217)
- 3-Aminotetrahydrothiophene-3-carboxylic acid 1,1-dioxide (CAS 40057-27-0)
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- CAS 287389-38-2 (CAS 287389-38-2)
- 1,2,3,4-Tetrahydrocyclopenta[b]indol-5-amine (CAS 1934827-89-0)
- 6-(2-(Trifluoromethyl)phenyl)picolinic acid (CAS 887983-43-9)
- Ioversol Impurity 10 (CAS CATO-C4X-209110)
- 3-Benzyl-9-oxo-3-azabicyclo[3.3.1]Nonane-1-carboxylic acid (CAS 1393383-35-1)
- Methyl 5-chloro-4-fluoro-2-(trifluoromethyl)benzoate (CAS 1805524-74-6)
- 5-Aminoisobenzofuran-1,3-dione (CAS 17011-53-9)
- Semaglutide Impurity 155 (x TFA Salt) (CAS CATO-C4X-2226155)
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