N-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-2-[(6-acetamidopyridin-3-yl)sulfanyl]benzamide CAS 338962-76-8
| CAS No. | 338962-76-8 |
| Molecular Formula | C26H18ClF3N4O3S |
| Molecular Weight | 558.96 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of N-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-2-[(6-acetamidopyridin-3-yl)sulfanyl]benzamide is closely related to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
N-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-2-[(6-acetamidopyridin-3-yl)sulfanyl]benzamide (CAS 338962-76-8), molecular formula C26H18ClF3N4O3S and molecular weight 558.96 g/mol, is a CATO reference standard with documented purity and traceability.
N-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-2-[(6-acetamidopyridin-3-yl)sulfanyl]benzamide (C26H18ClF3N4O3S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-2-[(6-acetamidopyridin-3-yl)sulfanyl]benzamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H18ClF3N4O3S |
| Molecular Weight | 558.96 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related N Standards
- [(1E)-3-(4-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}phenyl)-3-oxoprop-1-en-1-yl](methyl)amino 4-methylbenzoate (CAS 303151-66-8)
- N-(2-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-5-(trifluoromethyl)phenyl)-3-methoxybenzamide (CAS 478262-09-8)
- N-(6-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](methyl)amino}-2,5-dioxo-2H,5H,6H-pyrano[3,2-c]pyridin-3-yl)-3-(trifluoromethyl)benzamide (CAS 341966-33-4)
- 2-[(1E)-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-methylhydrazin-1-ylidene}methyl]-N,N'-bis(2-chlorophenyl)propanediamide (CAS 306978-29-0)
- 4-Chloro-2-(3-chlorophenyl)-5-(4-(2,6-dinitro-4-(trifluoromethyl)phenyl)piperazin-1-yl)pyridazin-3(2H)-one (CAS 477867-41-7)
- Methyl 6-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-[(E)-({[(4-chlorophenyl)methoxy]amino}methylidene)amino]-4H,5H,6H,7H-thieno[2,3-c]pyridine-3-carboxylate (CAS 321430-40-4)
- 2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-5-[5-({[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}methyl)-4,5-dihydro-1,2-oxazol-3-yl]-5-methyl-1,2,4-triazolidin-3-one (CAS 344276-82-0)
- 1-(5-Chloro-4-((8-methoxy-1-methyl-3-(2-(methylamino)-2-oxoethoxy)-2-oxo-1,2-dihydroquinolin-6-yl)amino)pyrimidin-2-yl)-N,N-dimethylpiperidine-4-carboxamide (CAS 2166387-64-8)
Recommended Standards
- 151237-06-8 1,2-Bis(hexadecyloxy)benzene DTXSID50566429 (CAS 151237-06-8)
- (<I>R,R</I>)-(-)-<I>N,N′</I>-bis(3,5-di-tert-butylsalicylidene)-1,2- Cyclohexanediamine (CAS 135616-40-9)
- Dotinurad Impurity 92 (CAS CATO-C4X-249492)
- (<I>S,S</I>)-(+)-<I>N,N′</I>-bis(3,5-di-tert-butylsalicylidene)-1,2- Cyclohexanediamine (CAS 135616-36-3)
- 3-Methoxypyridin-4(1H)-one (CAS 50700-60-2)
- 3-Bromo-4-(2-(pyrrolidin-1-yl)ethoxy)benzaldehyde (CAS 938310-95-3)
- N-(2-Cyclopropoxy-3-(dimethylamino)phenyl)methanesulfonamide (CAS 1243447-13-3)
- 3-(Difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carbaldehyde (CAS 1255947-44-4)
- 5-Chloro-thiophene-2-carboxylic Acid (CAS 799012-78-5)
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- 2-(Dimethoxymethyl)-2-methyl-6-nitro-2H-chromene (CAS 146821-84-3)
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- 2-Amino-N-ethyl-N-(3-fluorobenzyl)acetamide (CAS 1184827-69-7)
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