Belumosudil Impurity 47 CAS 3084112-89-7
| CAS No. | 3084112-89-7 |
| Molecular Formula | C25H21N5O3 |
| Molecular Weight | 439.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Belumosudil Impurity 47.
Belumosudil Impurity 47 (CAS 3084112-89-7) is a certified pharmaceutical impurity reference standard with the molecular formula C25H21N5O3 and a molecular weight of 439.47 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, Belumosudil Impurity 47 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 439.47 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H21N5O3 |
| Molecular Weight | 439.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2005 |
| Nitrogen Atoms | 5 |
Related Belumosudil Standards
- Belumosudil Impurity 46 (CAS 911417-84-0)
- Belumosudil (CAS 911417-87-3)
- Belumosudil Impurity 49 (CAS CATO-C4X-298849)
- Belumosudil Impurity N1 (CAS 911417-26-0)
- Belumosudil Impurity 42 (CAS CATO-C4X-298842)
- Belumosudil-d7 (CAS CATO-C4X-298826)
- Belumosudil Impurity 23 (CAS CATO-C4X-298823)
- Belumosudil Impurity 36 (CAS CATO-C4X-298836)
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