3-(2-Chlorophenyl)-5-methyl-N-[4-(trifluoromethoxy)phenyl]-1,2-oxazole-4-carboxamide CAS 309740-96-3
| CAS No. | 309740-96-3 |
| Molecular Formula | C18H12ClF3N2O3 |
| Molecular Weight | 396.75 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-(2-Chlorophenyl)-5-methyl-N-[4-(trifluoromethoxy)phenyl]-1,2-oxazole-4-carboxamide is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3-(2-Chlorophenyl)-5-methyl-N-[4-(trifluoromethoxy)phenyl]-1,2-oxazole-4-carboxamide (CAS 309740-96-3) is a high-purity analytical reference standard with the molecular formula C18H12ClF3N2O3 and a molecular weight of 396.75 g/mol.
3-(2-Chlorophenyl)-5-methyl-N-[4-(trifluoromethoxy)phenyl]-1,2-oxazole-4-carboxamide (C18H12ClF3N2O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H12ClF3N2O3 |
| Molecular Weight | 396.75 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chlorophenyl Standards
- [1-(4-Chlorophenyl)-1H-1,2,3-triazol-4-yl]methyl N-[3-(trifluoromethyl)phenyl]carbamate (CAS 338419-13-9)
- (5-((4-Chlorophenyl)sulfonyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methyl acetate (CAS 318469-27-1)
- Ethyl 4-(3-(4-chlorophenyl)benzo[c]isoxazole-5-carbonyl)isoxazole-3-carboxylate (CAS 337920-31-7)
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- N-[(4-Chlorophenyl)methyl]-7-fluoro-2-methyl-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxamide (CAS 338778-25-9)
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Recommended Standards
- 2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](methyl)amino}-1-oxo-1,2-dihydroisoquinoline-4-carboxamide (CAS 339106-89-7)
- 4-Cyanophenyl 3-(4-chlorophenyl)-3-(2,2,2-trifluoroacetamido)propanoate (CAS 866039-30-7)
- 1-(4-Chlorobenzyl)-3-(3-(trifluoromethyl)benzyl)imidazolidine-2,4,5-trione (CAS 478262-69-0)
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- (2S)-4-bromo-3-methoxy-2-methyl-2H-furan-5-one (CAS 2878423-98-2)
- n-(4,5,6,7-Tetrahydrothiazolo[5,4-c]pyridin-2-yl)cyclopropanecarboxamide hydrochloride (CAS 1351598-79-2)
- N-((1-Ethyl-4-methyl-1H-pyrazol-5-yl)methyl)-1,4-dimethyl-1H-pyrazol-3-amine hydrochloride (CAS 1855950-22-9)
- 4-Chloro-6-fluoroquinazoline (CAS 16499-61-9)
- 2,3-Dichloro-4-(difluoromethoxy)benzylamine (CAS 1803789-39-0)
- 1-{[4-(dimethylamino)phenyl]methyl}-1h-pyrazol-5-amine (CAS 3524-27-4)
- N1-(2-(Dimethylamino)ethyl)-N2-(2-((2-(dimethylamino)ethyl)(methyl)amino)ethyl)-N1,N2-dimethylethane-1,2-diamine (CAS 3083-11-2)
- 4-oxo-4-[5-(quinoxalin-6-yl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]butanoic acid (CAS 946279-09-0)
- 2-Ethylbutyric Acid (CAS 88-09-5)
- (Gly1,Ser3·22,Gln?·3?,Thr?,Arg1?,Tyr21,Ala23·31,Aib32)-Pancreatic Polypeptide (human) (CAS 313988-89-5)
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