2-(4-Chlorophenyl)-4-methyl-N-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxamide CAS 320420-80-2
| CAS No. | 320420-80-2 |
| Molecular Formula | C18H12ClF3N2OS |
| Molecular Weight | 396.81 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-(4-Chlorophenyl)-4-methyl-N-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxamide is closely related to a steroid core, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-(4-Chlorophenyl)-4-methyl-N-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxamide (CAS 320420-80-2) is a high-purity analytical reference standard with the molecular formula C18H12ClF3N2OS and a molecular weight of 396.81 g/mol.
Structurally, 2-(4-Chlorophenyl)-4-methyl-N-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxamide (C18H12ClF3N2OS) contains a steroid core, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 396.81 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H12ClF3N2OS |
| Molecular Weight | 396.81 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
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Recommended Standards
- 2-((N-Allyl-4-chloro-3-(trifluoromethyl)phenyl)sulfonamido)-N-cyclopropylacetamide (CAS 852941-46-9)
- 2-[2-(2-Chloro-6,7-dimethoxyquinolin-3-yl)ethyl]-1H-isoindole-1,3(2H)-dione (CAS 1105193-51-8)
- 2-(2-(2-Chloro-5,8-dimethoxyquinolin-3-yl)ethyl)isoindoline-1,3-dione (CAS 1105193-56-3)
- N1-(5-{[2-oxo-2-(2,3,4-trifluoroanilino)ethyl]thio}-1,3,4-thiadiazol-2-yl)-2-chloroacetamide (CAS 244639-93-8)
- 3-(4-Fluorophenyl)cyclobutan-1-amine (CAS 1156295-31-6)
- 2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)nicotinic acid (CAS 247582-73-6)
- Sennidin A (CAS 641-12-3)
- 2-Amino-1-(4-hydroxyphenyl)ethan-1-one (CAS 77369-38-1)
- 6-Nitro-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine (CAS 80773-01-9)
- 2-{[3-(2-methoxyethyl)-1,2,4-oxadiazol-5-yl]methoxy}acetic acid (CAS 1247904-12-6)
- 5-(p-Tolyl)-1H-1,2,3-triazole-4-carboxylic acid (CAS 1368022-26-7)
- (1R,3S,5R)-2-Azabicyclo[3.1.0]hexane-3-carboxylic acid (CAS 214193-12-1)
- 5-(Piperidin-1-yl)isoquinolin-8-amine (CAS 923211-75-0)
- 69558-55-0 O3Y80ZF13F Thymopentin Thymopentin [USAN:INN:BAN] L-Tyrosine, N-(N-(N-(N2-L-arginyl-L-lysyl)-L-alpha-aspartyl)-L-valyl)- L-Tyrosine, N-(N-(N-(N(sup 2)-L-arginyl-L-lysyl)-L-alpha-aspartyl)-L-valyl)- Thymopentine [French] Thymopentinum [Latin] Timopentina [Spanish] Thymopoietin 32-36 TP-5 Thymopoietin pentapeptide ORF-15244 Thymopentine Thymopentinum Timopentina ORF 15244 UNII-O3Y80ZF13F (CAS 69558-55-0)
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