4-Bromo-6-fluoro-2-(trifluoromethyl)quinoline CAS 31009-33-3
| CAS No. | 31009-33-3 |
| Molecular Formula | C10H4BrF4N |
| Molecular Weight | 294.04 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4-Bromo-6-fluoro-2-(trifluoromethyl)quinoline (CAS 31009-33-3), molecular formula C10H4BrF4N and molecular weight 294.04 g/mol, is a CATO reference standard with documented purity and traceability.
4-Bromo-6-fluoro-2-(trifluoromethyl)quinoline (C10H4BrF4N) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/bromine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H4BrF4N |
| Molecular Weight | 294.04 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1965 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromo Standards
- 4-Bromo-8-fluoro-6-(trifluoromethyl)quinoline (CAS 1375302-41-2)
- 8-Bromo-5-fluoro-2-(trifluoromethyl)quinoline (CAS 1425335-26-7)
- 2-Bromo-6-fluoro-4-(trifluoromethyl)quinoline (CAS 596845-30-6)
- 2-Bromo-8-fluoro-4-(trifluoromethyl)quinoline (CAS 663192-84-5)
- 4-Bromo-8-fluoro-2-(trifluoromethyl)quinoline (CAS 31008-96-5)
- 6-Bromo-2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4(3H)-one (CAS 52833-43-9)
- Methyl 5-bromo-2-fluoro-4-hydroxy-3-nitrobenzoate (CAS 2470065-23-5)
- 5-Bromo-7-(trifluoromethyl)indoline-2,3-dione (CAS 1067187-97-6)
Recommended Standards
- 4-Hydroxy-3-iodo-5-methoxybenzoic acid (CAS 98554-57-5)
- 4,6-Difluoro-3-iodo-1-methyl-1H-indazole (CAS 1824065-77-1)
- 5-iodo-4-(trifluoromethyl)thiazol-2-amine (CAS 682342-65-0)
- 6,8-Difluoro-1-iodo-3-methylimidazo[1,5-a]pyridine (CAS 1823916-32-0)
- N-(5-(tert-butyl)-1,3,4-thiadiazol-2-yl)-2-chloronicotinamide (CAS 866010-66-4)
- (1-(4-Chlorophenyl)ethyl)hydrazine hydrochloride (CAS 75333-16-3)
- Ethyl imidazo[2,1-b]thiazole-6-carboxylate (CAS 64951-04-8)
- Pyrazolo[1,5-a]pyridine-7-methanamine, hydrochloride (CAS 1187929-22-1)
- 3-Bromo-2,5,6-trimethoxypyridine (CAS 106331-72-0)
- 2-(Imidazo[2,1-b]thiazol-6-yl)-N-(4h-1,2,4-triazol-3-yl)acetamide (CAS 1050837-99-4)
- 2-(1-Methyl-1H-pyrazol-4-yl)tetrahydro-2H-pyran-4-carboxylic acid (CAS 2432830-23-2)
- 2-(4-Chlorophenyl)-1-(4-methoxyphenyl)-1,5,6,7,8,9-hexahydroimidazo[1,2-a]azepin-4-ium bromide (CAS 478945-28-7)
- 2-Methyl-4'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid (CAS 845826-90-6)
- Semaglutide impurity 29 (CAS CATO-C4X-222629)
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