(E)-4-[2-(2,4-Dichlorobenzoyl)hydrazino]-4-oxo-2-butenoic acid CAS 314767-12-9
| CAS No. | 314767-12-9 |
| Molecular Formula | C11H8Cl2N2O4 |
| Molecular Weight | 303.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (E)-4-[2-(2,4-Dichlorobenzoyl)hydrazino]-4-oxo-2-butenoic acid.
CATO supplies (E)-4-[2-(2,4-Dichlorobenzoyl)hydrazino]-4-oxo-2-butenoic acid (CAS 314767-12-9), a certified reference material (molecular formula C11H8Cl2N2O4, MW 303.10 g/mol) for analytical method development and quality control.
The molecular framework of (E)-4-[2-(2,4-Dichlorobenzoyl)hydrazino]-4-oxo-2-butenoic acid (C11H8Cl2N2O4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H8Cl2N2O4 |
| Molecular Weight | 303.10 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related E Standards
- 4-(2,5-Dichlorobenzoyl)isoquinoline (CAS 1187168-14-4)
- 1-(3,4-Dichlorobenzoyl)piperidine-4-carboxylic acid (CAS 147958-91-6)
- 4-(2,3-Dichlorobenzoyl)quinoline (CAS 1706429-88-0)
- 4-(2,4-Dichlorobenzoyl)quinoline (CAS 1706444-36-1)
- 4-(2,6-Dichlorobenzoyl)quinoline (CAS 1706444-39-4)
- 4-(2,5-Dichlorobenzoyl)quinoline (CAS 1706462-38-5)
- 4-(3,4-Dichlorobenzoyl)quinoline (CAS 1706462-39-6)
- 1-(3,4-Dichlorobenzoyl)piperidine-3-carboxylic acid (CAS 926246-92-6)
Recommended Standards
- 1-Bromo-4-(methylsulfonyl)-2-(trifluoromethyl)benzene (CAS 1820711-75-8)
- 1-(Bromomethyl)-3-((trifluoromethyl)sulfonyl)benzene (CAS 866208-07-3)
- 2-Bromo-1-(methylsulfonyl)-4-(trifluoromethyl)benzene (CAS 1820703-37-4)
- 1-Bromo-4-((2,2,2-trifluoroethyl)sulfonyl)benzene (CAS 648905-23-1)
- 2,6-Diamino-4-(6-chlorobenzo[d][1,3]dioxol-5-yl)-4H-thiopyran-3,5-dicarbonitrile (CAS 299168-59-5)
- Methyl 6-chlorothiazolo[4,5-b]pyridine-2-carboxylate (CAS 1440428-01-2)
- 7-Iodo-1H-indazol-5-amine (CAS 1208228-61-8)
- Tert-butyl (R)-3-(2-aminoethyl)morpholine-4-carboxylate (CAS 2165569-04-8)
- 6-Chloro-2-phenylnicotinic acid (CAS 1214328-53-6)
- 3-methyl-1-phenyl-4-(trifluoromethyl)-1H-pyrazol-5-amine (CAS 1235438-91-1)
- 1017778-27-6 5-Methyl-2-(trifluoromethyl)phenylacetic acid MFCD09832298 (CAS 1017778-27-6)
- 3-Fluoroimidazo[1,2-a]pyridine-2-carboxylic acid hydrochloride (CAS 1215783-26-8)
- (3S,4S)-3-tert-Butoxycarbonylamino-4-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester (CAS 708273-50-1)
- Semaglutide impurity 84 (CAS CATO-C4X-222684)
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