1,4-Bis(7-chloroquinolin-4-yl)piperazine CAS 31502-87-1
| CAS No. | 31502-87-1 |
| Molecular Formula | C22H18Cl2N4 |
| Molecular Weight | 409.31 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1,4-Bis(7-chloroquinolin-4-yl)piperazine (CAS 31502-87-1), molecular formula C22H18Cl2N4 and molecular weight 409.31 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 1,4-Bis(7-chloroquinolin-4-yl)piperazine (C22H18Cl2N4) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 15.0, corresponding to approximately 15 ring(s) or double-bond equivalent(s). With a molecular weight of 409.31 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H18Cl2N4 |
| Molecular Weight | 409.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Bis Standards
- 1-(7-Chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid (CAS 1146757-92-7)
- 12-((5-Chloroquinolin-8-yl)oxy)dodecyl acetate (CAS 88350-02-1)
- 4-[(7-Chloroquinolin-4-ylAmino]-2-(Diethylaminomethyl)-3,6-Difluorophenol (CAS 155020-40-9)
- (S)-1-(2-(3-(3-(2-(7-Chloroquinolin-2-yl)vinyl)phenyl)-3-hydroxypropyl)phenyl)ethan-1-one (CAS 144551-23-5)
- 4-(1-((7-Chloroquinolin-4-yl)amino)-4-(diethylamino)butan-2-yl)phenol (CAS 5431-70-9)
- 2-[(5-Chloroquinolin-8-yl)oxy]-N-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-5-yl)acetamide (CAS 874611-72-0)
- 5-Chloroquinolin-8-yl (2,5-dichlorophenyl)carbamate (CAS 21617-09-4)
- 5-Chloroquinolin-8-yl (3,4-dichlorophenyl)carbamate (CAS 21617-26-5)
Recommended Standards
- Methyl 3-{[(2,4-dichlorophenyl)carbamoyl]amino}-3-[4-(propan-2-yl)phenyl]propanoate (CAS 439094-79-8)
- Baclofen impurity 11 (CAS CATO-C4X-101211)
- 7,9-Dichloro-2-phenyl-5-(p-tolyl)-5,10b-dihydro-1H-benzo[e]pyrazolo[1,5-c][1,3]oxazine (CAS 302904-05-8)
- 9-(3-Bromophenyl)-10-phenylanthracene (CAS 1023674-80-7)
- (R)-Benzyl 2-amino-3-phenylpropanoate hydrochloride (CAS 87004-78-2)
- (S)-1-(8-Methylimidazo[1,2-a]pyridin-3-yl)ethanamine dihydrochloride (CAS 1373029-21-0)
- Methyl 2,2-dimethylthiazolidine-4-carboxylate (CAS 3963-75-5)
- Semaglutide Impurity 155 (x TFA Salt) (CAS CATO-C4X-2226155)
- (1-Benzylcyclopropyl)methanamine (CAS 91245-61-3)
- 9H-pyrido[2,3-b]indole-6-carboxylic acid (CAS 94718-66-8)
- Pemafibrate Impurity 17 (CAS CATO-C4X-290317)
- 2-(4,5-Dichloro-1H-imidazol-1-yl)-5-nitropyridine (CAS 1219550-27-2)
- 1-(Vinyloxy)octadecane (CAS 930-02-9)
- Semaglutide Impurity 6 (CAS 62-57-7)
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