8-Iodo-5-(trifluoromethyl)quinoline CAS 316-71-2
| CAS No. | 316-71-2 |
| Molecular Formula | C10H5F3IN |
| Molecular Weight | 323.05 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 8-Iodo-5-(trifluoromethyl)quinoline (C10H5F3IN) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/iodine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
8-Iodo-5-(trifluoromethyl)quinoline (CAS 316-71-2), molecular formula C10H5F3IN and molecular weight 323.05 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H5F3IN |
| Molecular Weight | 323.05 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/I-containing |
| Nitrogen Atoms | 1 |
Related Iodo Standards
- 4-Iodo-8-(trifluoromethyl)quinoline (CAS 1161941-01-0)
- 3-Iodo-7-(trifluoromethyl)quinoline (CAS 2384659-32-7)
- 4-Iodo-2-methoxy-5-nitrobenzoic acid (CAS 118137-59-0)
- 2-Iodo-4-(trifluoromethyl)thiazole-5-carboxylic acid (CAS 1205561-15-4)
- 3-Iodo-2,5,6-trimethoxyisonicotinaldehyde (CAS 1383788-27-9)
- 3-(4-Iodo-1h-pyrazol-1-yl)-2-(propylamino)propanoic acid (CAS 1339504-79-8)
- Ethyl 3-(4-iodo-1h-pyrazol-1-yl)-2-(methylamino)propanoate (CAS 1341523-24-7)
- 3-(4-Iodo-1h-pyrazol-1-yl)-2-(isopropylamino)propanoic acid (CAS 1341969-82-1)
Recommended Standards
- (2,2'-Bipyridyl)(1,5-cyclooctadiene)nickel (CAS 55425-72-4)
- 2-Bromo-4-fluorophenyl trifluoromethanesulfonate (CAS 885276-20-0)
- Pentafluoro(phenoxy)cyclotriphosphazene (CAS 33027-68-8)
- 4-Bromo-2-fluorophenyl trifluoromethanesulfonate (CAS 872054-03-0)
- 2,4,6-Trichloro-5-isopropylpyrimidine (CAS 1780-42-3)
- 2-Ethoxyhexa-3,5-diene (CAS 56752-55-7)
- 1-(2-Amino-5-methylphenyl)-2,2,2-trifluoroethan-1-one (CAS 205756-35-0)
- 2,4-Dimethyl-2H-benzo[e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxide (CAS 13338-03-9)
- 3-Bromotetrahydro-2H-thiopyran (CAS 32358-86-4)
- 1-(7-Methyl-6,7-dihydro-5H-cyclopenta[b]pyrazin-2-yl)propan-1-one (CAS 95576-07-1)
- 5,7-DIbromo-2-methyl-quinolin-8-ylamine (CAS 2104152-51-2)
- 1-(7-Methoxy-1H-indazol-3-yl)ethanone (CAS 1557700-47-6)
- N-(4-Ethoxybenzo[d]thiazol-2-yl)-1,4-dimethyl-1H-pyrazole-5-carboxamide (CAS 1207039-06-2)
- D-Ser12-Semaglutide (CAS CATO-C4X-2226240)
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