Adrenaline EP Impurity E HCl CAS 317351-39-6
| CAS No. | 317351-39-6 |
| Molecular Formula | C16H17NO3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Adrenaline EP Impurity E HCl.
As a process- or degradation-related impurity, Adrenaline EP Impurity E HCl (CAS 317351-39-6, C16H17NO3HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Adrenaline EP Impurity E HCl is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 307.77 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H17NO3 HCl |
| Molecular Weight | 307.77 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Adrenaline Standards
- Adrenaline Impurity 34 (CAS 1095714-91-2)
- rac-Adrenaline EP Impurity D TFA salt (CAS 1095714-91-2(Free Base))
- Adrenaline Impurity 88 (CAS 139183-81-6)
- Adrenaline Impurity 42 (CAS 18191-22-5)
- Adrenaline Impurity 23 (CAS 1894824-44-2)
- Adrenaline Impurity 16 (CAS 2234-25-5)
- Rac-Adrenaline EP Impurity F (Epinephrine Sulfonic Acid) (CAS 26405-77-6)
- Adrenaline Impurity 17 HCl (CAS 29705-82-6)
Recommended Standards
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- CAS 1333998-21-2 (CAS 1333998-21-2)
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- Iguratimod Impurity 52 (CAS 82780-78-7)
- 2-(2,4-Dichlorophenyl)-1-(4-methoxyphenyl)ethan-1-one (CAS 153529-19-2)
- tert-Butyl 7-((methylsulfonyl)oxy)-2-azaspiro[3.5]nonane-2-carboxylate (CAS 1421270-78-1)
- (D-Trp32)-Neuropeptide Y (porcine) trifluoroacetate salt (CAS 153549-78-1)
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