Adrenaline Impurity 42 CAS 18191-22-5
| CAS No. | 18191-22-5 |
| Molecular Formula | C9H13NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Adrenaline Impurity 42 (CAS 18191-22-5, C9H13NO2HBr) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, Adrenaline Impurity 42 is typically white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 248.12 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H13NO2 HBr |
| Molecular Weight | 248.12 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Adrenaline Standards
- Adrenaline Impurity 34 (CAS 1095714-91-2)
- rac-Adrenaline EP Impurity D TFA salt (CAS 1095714-91-2(Free Base))
- Adrenaline Impurity 88 (CAS 139183-81-6)
- Adrenaline Impurity 23 (CAS 1894824-44-2)
- Adrenaline Impurity 16 (CAS 2234-25-5)
- Rac-Adrenaline EP Impurity F (Epinephrine Sulfonic Acid) (CAS 26405-77-6)
- Adrenaline Impurity 17 HCl (CAS 29705-82-6)
- Adrenaline Impurity 95 (CAS 2972574-99-3)
Recommended Standards
- Tucatinib Impurity 5 (CAS CATO-C4X-26055)
- Aprepitant Impurity 70 (CAS 419574-15-5)
- Metaraminol Impurity 78 (CAS 65133-68-8)
- N-(5-Chloro-1H-indol-1-yl)-1-propylpiperidine-3-carboxamide (CAS 919102-49-1)
- 2-Bromo-6-(difluoromethyl)-3-fluoropyridine-4-sulfonamide (CAS 1805411-19-1)
- Ethyl 3-(3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)-3-oxopropanoate (CAS 1807546-68-4)
- Cyclohexanol, 2-(1,1-dimethylethyl)-, (1R,2S)-rel- (CAS 5448-22-6)
- 2-(3-Ethoxy-4-fluorophenyl)ethan-1-ol (CAS 1378819-19-2)
- Acenocoumarol Impurity 12 (CAS 63986-29-8)
- (Cys2)-Neuropeptide Y-8-aminooctanoyl-(D-Cys27)-Neuropeptide Y (25-32) (H-3298.0500) (CAS 128806-04-2)
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