Ethyl 5-amino-2-phenylthiazole-4-carboxylate CAS 31785-06-5
| CAS No. | 31785-06-5 |
| Molecular Formula | C12H12N2O2S |
| Molecular Weight | 248.30 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Ethyl 5-amino-2-phenylthiazole-4-carboxylate (CAS 31785-06-5), molecular formula C12H12N2O2S and molecular weight 248.30 g/mol, is a CATO reference standard with documented purity and traceability.
Ethyl 5-amino-2-phenylthiazole-4-carboxylate (C12H12N2O2S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H12N2O2S |
| Molecular Weight | 248.30 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Ethyl Standards
- 4'-Amino-[1,1'-biphenyl]-4-sulfonamide (CAS 100142-87-8)
- 2-Amino-5-m-tolyl-thiazole-4-carboxylic acid methyl ester (CAS 1007874-30-7)
- N-(4-amino-2-methoxyphenyl)thiophene-2-carboxamide (CAS 110506-36-0)
- 3-Amino-1-methyl-4-(thiophen-2-yl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-one (CAS 1105190-99-5)
- Methyl 2-amino-4-p-tolylthiazole-5-carboxylate (CAS 1133115-44-2)
- Methyl 3-amino-6-cyclopropylthieno[2,3-b]pyridine-2-carboxylate (CAS 1135283-79-2)
- Ethyl 2-amino-4-(pyridin-4-yl)thiophene-3-carboxylate (CAS 117516-88-8)
- N-(2-(5-amino-1,3,4-thiadiazol-2-yl)ethyl)benzamide (CAS 1199215-56-9)
Recommended Standards
- Ethyl 5-(2-methylphenyl)-1,3,4-thiadiazole-2-carboxylate (CAS 1986907-98-5)
- Ethyl 5-methyl-2-(pyridin-3-yl)thiazole-4-carboxylate (CAS 39067-25-9)
- Ethyl 4-methyl-2-(pyridin-4-yl)thiazole-5-carboxylate (CAS 89401-54-7)
- Methyl 1-benzyl-2-mercapto-1H-imidazole-5-carboxylate (CAS 76075-15-5)
- 4-Ethynyl-2,6-dimethylphenol (CAS 374067-81-9)
- 3-(1,3-Dioxolan-2-yl)-3-trifluoromethyl-benzophenone (CAS 514802-37-0)
- 5-(1-Butylpiperidin-2-yl)-N-cyclobutylpyridin-2-amine (CAS 1352507-81-3)
- 1-(Isocyanatomethyl)naphthalene (CAS 61924-27-4)
- (S)-2-((Dimethoxyphosphoryl)amino)pentanedioic acid (CAS 211631-99-1)
- Hexahydro-4-oxo-1(2H)-azocinecarboxylic Acid 1,1-Dimethylethyl Ester (CAS 1803599-91-8)
- 1-(Iodomethyl)bicyclo[2.2.1]heptane (CAS 61192-16-3)
- 2-Allyl-4-aminophenol (CAS 35736-25-5)
- (3-Butoxy-5-(trifluoromethoxy)phenyl)boronic acid (CAS 1256345-96-6)
- Semaglutide impurity 25 (CAS CATO-C4X-222625)
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