1-(6-Chloropyridin-2-yl)-N-methyl-4-nitro-1H-pyrazol-5-amine CAS 318238-09-4
| CAS No. | 318238-09-4 |
| Molecular Formula | C9H8ClN5O2 |
| Molecular Weight | 253.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(6-Chloropyridin-2-yl)-N-methyl-4-nitro-1H-pyrazol-5-amine.
1-(6-Chloropyridin-2-yl)-N-methyl-4-nitro-1H-pyrazol-5-amine (CAS 318238-09-4), molecular formula C9H8ClN5O2 and molecular weight 253.65 g/mol, is a CATO reference standard with documented purity and traceability.
1-(6-Chloropyridin-2-yl)-N-methyl-4-nitro-1H-pyrazol-5-amine (C9H8ClN5O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H8ClN5O2 |
| Molecular Weight | 253.65 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Chloropyridin Standards
- 1-(3-Chloropyridin-2-yl)-3-methoxy-1h-pyrazole-5-carboxylic acid (CAS 1122021-75-3)
- Ethyl 3-(2-chloropyridin-4-yl)-1,2,4-oxadiazole-5-carboxylate (CAS 1219571-90-0)
- 3-(3-(2-Chloropyridin-4-yl)-1,2,4-oxadiazol-5-yl)propanoic acid (CAS 1255099-24-1)
- Ethyl 3-(2-chloropyridin-3-yl)-1,2,4-oxadiazole-5-carboxylate (CAS 890095-91-7)
- (6-Chloropyridin-3-yl)(3,4-difluorophenyl)methanone (CAS 1187169-69-2)
- (6-Chloropyridin-3-yl)(2,6-difluorophenyl)methanone (CAS 490038-59-0)
- 3-[(6-chloropyridin-3-yl)methyl]-5,5-dimethylimidazolidine-2,4-dione (CAS 1016720-44-7)
- 1-(2-((5-Chloropyridin-2-yl)amino)thiazol-5-yl)ethan-1-one (CAS 952183-72-1)
Recommended Standards
- 2-Butoxy-3-chloro-5-(trifluoromethyl)pyridine (CAS 1881321-49-8)
- 2-(2-Chloro-5-methylphenoxy)-3,3,3-trifluoropropan-1-amine (CAS 886764-64-3)
- 3-Chloro-2-(2-methylpropoxy)-5-(trifluoromethyl)pyridine (CAS 1881295-26-6)
- 2-chloro-1-[2,5-dimethyl-1-(2,2,2-trifluoroethyl)-1H-pyrrol-3-yl]ethanone (CAS 746630-82-0)
- 1-Ethyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperazine (CAS 364794-83-2)
- 44463-62-9 Tetraamminepalladium(II) bromide, Premion? MFCD00797352 (CAS 44463-62-9)
- 2-Amino-5-(2-chloropyrimidin-4-yl)benzonitrile (CAS 1292317-50-0)
- Methyl 2-cyano-3-fluorobenzoate (CAS 1261476-54-3)
- Methyl 3-[4-(ethylcarbamoyl)-3-fluorophenyl]-2-fluorobenzoate (CAS 1381944-66-6)
- Methoxymethoxy Nefazodone (CAS 1346604-95-2)
- (S)-Oxetan-2-ylmethanamine 4-methylbenzenesulfonate (CAS 2740593-38-6)
- 4-(4-Methoxyphenyl)-5-(methylsulfonyl)-1,2,3-thiadiazole (CAS 1713655-98-1)
- Trans-6-phenyl-2-hexene (CAS 23086-43-3)
- Fibrinopeptide A, human TFA (CAS 61533-47-9)
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