4-(Benzenesulfonyl)-1-(2,5-dichlorophenyl)-5-(4-fluorophenyl)-1H-pyrazole CAS 318951-71-2
| CAS No. | 318951-71-2 |
| Molecular Formula | C21H13Cl2FN2O2S |
| Molecular Weight | 447.31 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(Benzenesulfonyl)-1-(2,5-dichlorophenyl)-5-(4-fluorophenyl)-1H-pyrazole.
4-(Benzenesulfonyl)-1-(2,5-dichlorophenyl)-5-(4-fluorophenyl)-1H-pyrazole (CAS 318951-71-2), molecular formula C21H13Cl2FN2O2S and molecular weight 447.31 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-(Benzenesulfonyl)-1-(2,5-dichlorophenyl)-5-(4-fluorophenyl)-1H-pyrazole (C21H13Cl2FN2O2S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4-(Benzenesulfonyl)-1-(2,5-dichlorophenyl)-5-(4-fluorophenyl)-1H-pyrazole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H13Cl2FN2O2S |
| Molecular Weight | 447.31 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Benzenesulfonyl Standards
- 4-(Benzenesulfonyl)-5-(3,4-dichlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole (CAS 318951-73-4)
- 3-(Benzenesulfonyl)-N-(2-methoxy-5-methylphenyl)-[1,2,3]triazolo[1,5-a]quinazolin-5-amine (CAS 866811-47-4)
- [5-(Benzenesulfonyl)-1-methyl-3-phenyl-1H-pyrazol-4-yl]methyl 4-fluorobenzoate (CAS 318289-30-4)
- 3-(Benzenesulfonyl)-6,8-dibromo-2H-chromen-2-one (CAS 1351804-74-4)
- (2Z)-2-(Benzenesulfonyl)-3-[3-(2,3-dihydro-1H-inden-5-yl)-1-phenyl-1H-pyrazol-4-yl]prop-2-enenitrile (CAS 956923-23-2)
- 4-(Benzenesulfonyl)-2-[(4-methylphenyl)methanesulfonyl]-5,6,7,8-tetrahydroquinazoline (CAS 478067-50-4)
- 5-(Benzenesulfonyl)-4-(2,4-dichlorophenyl)-2-(pyridin-3-yl)pyrimidine (CAS 339108-13-3)
- 5-(Benzenesulfonyl)-4-(3,4-dichlorophenyl)-2-(pyridin-2-yl)pyrimidine (CAS 339107-70-9)
Recommended Standards
- 2,5-Dichloro-3,6-bis((4-ethoxyphenyl)amino)cyclohexa-2,5-diene-1,4-dione (CAS 29027-10-9)
- 2,4-Dichloro-5-(n-(6-ethoxybenzo[d]thiazol-2-yl)sulfamoyl)benzoic acid (CAS 692745-62-3)
- Lifitegrast Impurity 45 (CAS CATO-C4X-240945)
- 4'-Iodo-N,N-diphenyl-[1,1'-biphenyl]-4-amine (CAS 167218-38-4)
- 4-(Dimethylphosphoryl)benzoic acid (CAS 53888-91-8)
- 2-[5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-2-(4-methoxyphenyl)acetonitrile (CAS 478043-31-1)
- (2-(Methylsulfonyl)phenyl)boronic acid (CAS 330804-03-0)
- 6,7-Bis(4-methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidine (CAS 685107-35-1)
- 4-Chloro-3-(6-methylbenzo[d]oxazol-2-yl)aniline (CAS 293737-71-0)
- Lefamulinum Impurity 12 (CAS CATO-C4X-304712)
- 2-(Thiophen-2-ylsulfonyl)ethanethioamide (CAS 175202-34-3)
- 4-(Bromomethyl)-5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazole (CAS 656825-78-4)
- 3-Bromo-2-methylbenzohydrazide (CAS 108485-07-0)
- D-Ser32-Tirzepatide (CAS CATO-CPTD788677)
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