Lifitegrast Impurity 45 CAS CATO-C4X-240945
| CAS No. | CATO-C4X-240945 |
| Molecular Formula | C21H20Cl2N4O3 |
| Molecular Weight | 447.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 447.31 g/mol gives Lifitegrast Impurity 45 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Lifitegrast Impurity 45 (CAS CATO-C4X-240945), a pharmacopoeial impurity reference standard (molecular formula C21H20Cl2N4O3, MW 447.31 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Lifitegrast Impurity 45 (C21H20Cl2N4O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Lifitegrast Impurity 45 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H20Cl2N4O3 |
| Molecular Weight | 447.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Lifitegrast Standards
- Lifitegrast Impurity 9 (CAS 1289646-72-5)
- Lifitegrast Impurity 13 (CAS CATO-C4X-240913)
- Lifitegrast Impurity 135 (CAS CATO-C4X-2409135)
- Lifitegrast Impurity 166 (CAS CATO-C4X-2409166)
- Lifitegrast Impurity 100 (CAS CATO-C4X-2409100)
- Lifitegrast Impurity 65 (CAS 2637374-15-1)
- Lifitegrast Impurity 172 (CAS CATO-C4X-2409172)
- Lifitegrast Impurity 154 (CAS CATO-C4X-2409154)
Recommended Standards
- 4-(Benzenesulfonyl)-5-(3,4-dichlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole (CAS 318951-73-4)
- 2,10-Bis(4-chlorophenyl)-1,2,4,9,10,12-hexaazadispiro[4.2.4^{8}.2^{5}]tetradecane-3,11-dione (CAS 338956-29-9)
- 4-(Benzenesulfonyl)-1-(2,5-dichlorophenyl)-5-(4-fluorophenyl)-1H-pyrazole (CAS 318951-71-2)
- 6-Bromo-5,8-bis((2-methoxyethoxy)methoxy)-2,2-dimethyl-2H-chromene (CAS 557757-31-0)
- Minocycline Impurity 71 (CAS CATO-C4X-169971)
- Mivacurium Chloride Impurity 22 (CAS CATO-C4X-137522)
- Fesoterodine Impurity 21 (CAS 1391913-28-2)
- 3-(1-Methylpiperidin-2-yl)pyridin-2-amine (CAS 54674-73-6)
- 3-Cyclopropyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine-7-carboxylic acid (CAS 1095826-32-6)
- 4-Pyreneacetic Acid (CAS 22245-55-2)
- O,O-Dimethyl (1,3-dithiolan-2-ylidene)phosphoramidothioate (CAS 3572-55-2)
- (2R,3R)-1-Chloro-2-hydroxy-3-[(benzyloxycarbonyl)amino]-4-(phenylthio)butane (CAS 194086-27-6)
- 2-Morpholinopyrimidine-5-carbonitrile (CAS 400082-62-4)
- Xenopsin-Related Peptide 2 (XP-2) (H-9340.0005) (CAS 117442-29-2)
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