Epinephrine Impurity 8 HCl (Mixture of Diastereomers) CAS 3198-07-0
| CAS No. | 3198-07-0 |
| Molecular Formula | C10H15NO3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Epinephrine Impurity 8 HCl (Mixture of Diastereomers) (C10H15NO3HCl) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO supplies Epinephrine Impurity 8 HCl (Mixture of Diastereomers) (CAS 3198-07-0), a pharmacopoeial impurity reference standard (molecular formula C10H15NO3HCl, MW 233.69 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H15NO3 HCl |
| Molecular Weight | 233.69 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Epinephrine Standards
- Epinephrine Impurity 10 (CAS 101724-21-4)
- Epinephrine Impurity 99 (CAS 1188265-23-7)
- Epinephrine Impurity 63 HCl (CAS 1188265-23-7 (free base))
- rac-Epinephrine-d3 (CAS 1189977-29-4)
- L-(-)-Epinephrine-d3 (CAS 1217733-17-9)
- (±)-Epinephrine-2,5,6,α,β,β-d6 (CAS 1219803-77-6)
- Epinephrine Sulfonic Acid-d3 (CAS 1346604-55-4)
- D-(+)-Epinephrine (CAS 150-05-0)
Recommended Standards
- Nintedanib Impurity 26 (CAS CATO-C4X-181426)
- Loxoprofen Dihydroxy Impurity (CAS 88378-22-7)
- Eperisone impurity 12 (CAS 760137-20-0)
- 5H,6H,7H-pyrrolo[1,2-b][1,2,4]triazol-6-ol (CAS 153851-41-3)
- (3E)-5-bromo-3-[(2,4-difluorophenyl)imino]-2,3-dihydro-1H-indol-2-one 118416-28-7 MS-8800 (CAS 118416-28-7)
- 1-Methyl-1,4,5,6,7,8-hexahydrocyclohepta[d]imidazole-2-carbaldehyde (CAS 1706449-28-6)
- 2-Bromo-3-iodobenzoyl chloride (CAS 1261816-81-2)
- 1-(2-Ethylphenyl)-5-phenyl-4,5-dihydro-1h-pyrazole-3-carboxylic acid (CAS 1264050-18-1)
- 6-Hydroxypyridine-3-sulfonic acid (CAS 6684-46-4)
- Peptide Impurity 28 (CAS 1350456-64-2)
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