5-[(2-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}ethyl)amino]-1,2,3,4-tetrahydropyrimidine-2,4-dione CAS 321432-02-4
| CAS No. | 321432-02-4 |
| Molecular Formula | C16H18ClF3N6O2 |
| Molecular Weight | 418.80 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5-[(2-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}ethyl)amino]-1,2,3,4-tetrahydropyrimidine-2,4-dione is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
5-[(2-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}ethyl)amino]-1,2,3,4-tetrahydropyrimidine-2,4-dione (CAS 321432-02-4) is a high-purity analytical reference standard with the molecular formula C16H18ClF3N6O2 and a molecular weight of 418.80 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 5-[(2-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}ethyl)amino]-1,2,3,4-tetrahydropyrimidine-2,4-dione is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 418.80 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 5-[(2-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}ethyl)amino]-1,2,3,4-tetrahydropyrimidine-2,4-dione meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H18ClF3N6O2 |
| Molecular Weight | 418.80 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 6 |
Related chloro Standards
- 11-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-5,11,12,12a-tetrahydropyrazolo[3',4':4,5]pyrido[2,1-a]isoquinolin-8(6H)-one (CAS 339012-01-0)
- (2R)-3-Chloro-2-[[4-(trifluoromethoxy)phenyl]methoxy]propyl ester 4-Methoxybenzoic Acid (CAS 1253202-35-5)
- 4-Chloro-N-[3-(5-(trifluoromethyl)pyridin-2-yl)-[1,2,4]--oxadiazol-5-ylmethyl]benzenesulphonamide (CAS 1311278-40-6)
- 2-Chloro-N-[5-(5-(trifluoromethyl)pyridin-2-yl)--[1,2,4]oxadiazol-3-ylmethyl]benzenesulphonamide (CAS 1311279-94-3)
- Ethyl 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-{[(4-fluorophenyl)methyl]carbamoyl}acetate (CAS 478063-75-1)
- N-(4-chloro-2-fluorophenyl)-3-(4-methoxyphenyl)-3-(2,2,2-trifluoroacetamido)propanamide (CAS 439108-90-4)
- (6-{3-[(4-Chloro-phenyl)-hydrazonomethyl]-phenyl}-4-trifluoromethyl-pyridin-2-yl)-dimethyl-amine (CAS 1311283-91-6)
- (6-{4-[(4-Chloro-phenyl)-hydrazonomethyl]-phenyl}-4-trifluoromethyl-pyridin-2-yl)-dimethyl-amine (CAS 1311283-99-4)
Recommended Standards
- N'-[(1E)-[2-(4-Chlorophenoxy)phenyl]methylidene]-4-(trifluoromethyl)benzohydrazide (CAS 338393-72-9)
- 1-(2-(1H-indol-3-yl)ethyl)-5-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)pyrimidin-4(1H)-one (CAS 551930-80-4)
- 5-Amino-N-(5-chloro-2-methoxyphenyl)-1-{[(2-fluorophenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide (CAS 901046-29-5)
- 2-(4-Chlorophenyl)-2-oxoethyl 2-acetamido-2-[(4-methoxyphenyl)carbamoyl]acetate (CAS 551920-98-0)
- 4-((5-Bromo-2-fluorophenyl)sulfonyl)morpholine (CAS 1643915-62-1)
- 4-Methyl-2H-pyran-2-one (CAS 22682-12-8)
- 4-(Pyridin-2-yl)aniline dihydrochloride (CAS 856849-12-2)
- 6-Bromo-7-methyl-3-nitroimidazo[1,2-a]pyridine (CAS 1072944-64-9)
- 1-(2-Amino-4-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanone (CAS 2415255-61-5)
- 2,4,7-Trichloro-6-fluoroquinazoline (CAS 174566-16-6)
- 1-(1,3-Dimethyl-1H-indol-2-yl)butan-1-one (CAS 425373-45-1)
- Dapoxetine Impurity 91 (CAS CATO-C4X-143991)
- 1-(Bromomethyl)-1,2,3,4-tetrahydroisoquinoline (CAS 130109-95-4)
- Semaglutide impurity 258 (CAS CATO-C4X-2226258)
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