5-(((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-N'-(4-chlorobenzoyl)-4,5-dihydroisoxazole-3-carbohydrazide CAS 321432-35-3
| CAS No. | 321432-35-3 |
| Molecular Formula | C18H14Cl2F3N5O3 |
| Molecular Weight | 476.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-(((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-N'-(4-chlorobenzoyl)-4,5-dihydroisoxazole-3-carbohydrazide.
5-(((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-N'-(4-chlorobenzoyl)-4,5-dihydroisoxazole-3-carbohydrazide (CAS 321432-35-3), molecular formula C18H14Cl2F3N5O3 and molecular weight 476.24 g/mol, is a CATO reference standard with documented purity and traceability.
5-(((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-N'-(4-chlorobenzoyl)-4,5-dihydroisoxazole-3-carbohydrazide (C18H14Cl2F3N5O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H14Cl2F3N5O3 |
| Molecular Weight | 476.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Chloro Standards
- 4-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-[(1E)-{[(4-chlorophenyl)methoxy]amino}methylidene]piperazine-1-carboxamide (CAS 338979-05-8)
- 6-Chloro-1-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}ethyl)-3-[(2-methoxyethyl)amino]-1,2-dihydroquinoxalin-2-one (CAS 303986-16-5)
- 2-Chloro-1-[1-[(3,4-diethoxyphenyl)methyl]-6,7-diethoxy-3,4-dihydro-2(1H)-isoquinolinyl]ethanone (CAS 730949-62-9)
- N-(4-Chloro-3-(trifluoromethyl)phenyl)-2-((3-ethyl-5,6-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)acetamide (CAS 618427-57-9)
- 3-Chloro-2-({7-[(Z)-2-[4-(propan-2-yl)phenyl]ethenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}sulfanyl)-5-(trifluoromethyl)pyridine (CAS 303986-70-1)
- 5-Chloro-1-(2,4-dichlorobenzyl)-N-(3,5-dichlorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (CAS 242797-25-7)
- (6S)-2-[(3-Chloro-4-fluorophenyl)methyl]-N,8-diethyl-1,2,6,7,8,9-hexahydro-10-hydroxy-6-methyl-1,9-dioxo-pyrazino[1,2:1,5]pyrrolo[2,3-d]pyridazine-4-carboxam (CAS 870005-19-9)
- N-(2-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)pyridin-3-yl)-4-methylbenzamide (CAS 478262-12-3)
Recommended Standards
- PD 198306 (CAS 212631-61-3)
- Dabrafenib Impurity 10 (CAS CATO-C4X-303310)
- 1,2-Bis(2-bromophenyl)-5,6,7,8-tetrahydroquinazoline-4(1H)-thione (CAS 62721-85-1)
- 1,1-Bis(4-chlorophenyl)-2-(3,4-dichlorobenzenesulfonyl)ethan-1-ol (CAS 303152-13-8)
- (2-Amino-6-ethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)(piperidin-1-yl)methanone (CAS 590351-61-4)
- (S)-N1-Methyl-N1-(1-methylpiperidin-3-yl)ethane-1,2-diamine (CAS 1354000-67-1)
- 2-Chloro-3-(phenylamino)-2-propenal (CAS 131139-84-9)
- 1-[5-(difluoromethyl)-1,2,4-oxadiazol-3-yl]cyclobutan-1-amine hydrochloride (CAS 1423029-04-2)
- 2-(5-Isopropyl-2-oxopiperazin-1-yl)acetic acid (CAS 1060808-12-9)
- 5-(Ethoxycarbonyl)-4-methyl-3-(propionyloxy)-1H-pyrrole-2-carboxylic acid (CAS 5450-16-8)
- 3,4-dimethyl-1H-pyrrole-2-carboxylic acid (CAS 89776-55-6)
- 3-(Methylsulfanyl)propane-1-thiol (CAS 26718-09-2)
- N-Ethyl-5-nitropicolinamide (CAS 1437794-42-7)
- [Glu]17-Semaglutide (CAS CATO-CPTD788604)
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