N-(2-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)pyridin-3-yl)-4-methylbenzamide CAS 478262-12-3
| CAS No. | 478262-12-3 |
| Molecular Formula | C23H21ClF3N5O |
| Molecular Weight | 475.89 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 475.89 g/mol gives N-(2-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)pyridin-3-yl)-4-methylbenzamide distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
N-(2-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)pyridin-3-yl)-4-methylbenzamide (CAS 478262-12-3) is a high-purity analytical reference standard with the molecular formula C23H21ClF3N5O and a molecular weight of 475.89 g/mol.
The molecular framework of N-(2-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)pyridin-3-yl)-4-methylbenzamide (C23H21ClF3N5O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-(2-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)pyridin-3-yl)-4-methylbenzamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H21ClF3N5O |
| Molecular Weight | 475.89 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related N Standards
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- 3-Chloro-2-({7-[(Z)-2-[4-(propan-2-yl)phenyl]ethenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}sulfanyl)-5-(trifluoromethyl)pyridine (CAS 303986-70-1)
- (2Z)-2-[(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)methylidene]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one 1025277-30-8 MS-9216 (CAS 1025277-30-8)
- 6-Chloro-7-methoxy-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one (CAS 1354745-52-0)
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- 3-(2-Chloro-6-fluorophenyl)-5-methyl-N-{3-[5-(trifluoromethyl)pyridin-2-yl]phenyl}-1,2-oxazole-4-carboxamide (CAS 1092346-37-6)
- 2-Chloro-1-[1-[(3,4-diethoxyphenyl)methyl]-6,7-diethoxy-3,4-dihydro-2(1H)-isoquinolinyl]ethanone (CAS 730949-62-9)
Recommended Standards
- 4-[6-(4-Methyl-piperazin-1-yl)-5-trifluoromethyl-pyridin-3-yl]-benzoic acid 4-chloro-phenyl ester (CAS 1311279-90-9)
- Metazosulfuron (CAS 868680-84-6)
- Dotinurad Impurity 95 (CAS CATO-C4X-249495)
- Methyl 2-[bis(2,2,2-trifluoroethoxy)phosphoryl]-2,2-dibromo-acetate (CAS 318967-86-1)
- 3-(5-(Allylthio)-4-ethyl-4H-1,2,4-triazol-3-yl)-1-(4-chlorophenyl)pyridazin-4(1H)-one (CAS 478077-59-7)
- Ethyl 3-cyano-1H-indole-6-carboxylate (CAS 1403746-46-2)
- Benzo[c]cinnoline 5-oxide (CAS 7334-10-3)
- Ethyl 5-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)isoxazole-3-carboxylate (CAS 925007-02-9)
- 6-Methoxyspiro[benzo[e][1,3]oxazine-2,4'-piperidin]-4(3H)-one hydrochloride (CAS 1204346-31-5)
- N1-methyl-N1-(2-phenylcyclopropyl)ethane-1,2-diamine (CAS 1876150-56-9)
- Vibegron Impurity 17 (CAS CATO-C4X-237617)
- 5-Chloro-3-ethoxy-2-nitropyridine (CAS 847902-51-6)
- N-(5-Amino-2-methylphenyl)-2-(4-chlorophenoxy)-acetamide (CAS 954264-30-3)
- Glucagon-like peptide 2 (CAS 89750-15-2)
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