(2E)-2-{1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-indol-3-yl}-3-(2-chlorophenyl)prop-2-enenitrile CAS 321433-37-8
| CAS No. | 321433-37-8 |
| Molecular Formula | C23H12Cl2F3N3 |
| Molecular Weight | 458.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies (2E)-2-{1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-indol-3-yl}-3-(2-chlorophenyl)prop-2-enenitrile (CAS 321433-37-8), a certified reference material (molecular formula C23H12Cl2F3N3, MW 458.26 g/mol) for analytical method development and quality control.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution, (2E)-2-{1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-indol-3-yl}-3-(2-chlorophenyl)prop-2-enenitrile is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 458.26 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO manufactures (2E)-2-{1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-indol-3-yl}-3-(2-chlorophenyl)prop-2-enenitrile under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C23H12Cl2F3N3 |
| Molecular Weight | 458.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related E Standards
- (2E)-2-{1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-indol-3-yl}-3-(4-chlorophenyl)prop-2-enenitrile (CAS 321433-36-7)
- 4-Chloro-N-{[5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl}-N-(4-methoxyphenyl)benzamide (CAS 956184-23-9)
- 3-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanyl}phenyl)-1-(4-chlorophenyl)urea (CAS 338773-29-8)
- 1-((5-Chloro-1,3-dimethyl-1H-pyrazol-4-yl)sulfonyl)-4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine (CAS 318247-34-6)
- 5-[(1E)-1-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]hydrazin-1-ylidene}ethyl]-1-(4-chlorophenyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione (CAS 321432-27-3)
- Ethyl 3-(2-chloro-6-fluorophenyl)-2-[3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl]propanoate (CAS 477860-54-1)
- 2-(2-(3-(2-(7-Chloro-2-quinolinyl)-ethenylphenyl)-3-hydroxypropyl)phenyl)-2-propanol (CAS 142569-70-8)
- 2,2'-(2-Chloro-2'-fluoro-[1,1'-biphenyl]-3,3'-diyl)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane) (CAS 2374861-97-7)
Recommended Standards
- 2-((5-(2-Bromophenyl)-1,3,4-oxadiazol-2-yl)thio)-N-(2-(trifluoromethyl)phenyl)acetamide (CAS 332170-99-7)
- ({5-(2-bromophenyl)-4-[3-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}thio)acetic acid (CAS 743439-42-1)
- Vinyltriethylsilane(hexafluoroacetylacetonato)silver(I) (CAS 177279-28-6)
- N-(3,5-Dichloropyridin-4-yl)-2-[1-(4-fluorobenzyl)-5-hydroxy-1H-indol-3-yl]-2-oxo-acetamide (CAS 257892-33-4)
- Methyl 5-hydroxy-4-methoxy-2-methylbenzoate (CAS 131236-68-5)
- N1-benzyl-N1,N3-dimethylpropane-1,3-diamine (CAS 60630-68-4)
- (3-Methoxyphenyl)(piperidin-4-yl)methanol (CAS 1082502-18-8)
- 2-Amino-4-methyl-N-phenylpyrimidine-5-carboxamide (CAS 400074-73-9)
- 1-[2-(1H-pyrazol-1-yl)ethyl]-1H-pyrazole-3-carboxylic acid (CAS 1341921-76-3)
- 3-(dimethylamino)cyclohexane-1-carboxylic acid (CAS 36268-42-5)
- 4-Chloro-2-(4-methoxyphenyl)-5-(piperidin-1-yl)pyridazin-3(2H)-one (CAS 477867-43-9)
- 3,5-Dibromoethoxybenzene (CAS 136265-19-5)
- Tert-butyl 3-(bromomethyl)-6-fluoro-1H-indazole-1-carboxylate (CAS 174180-95-1)
- 59880-97-6 Chemotactic peptide F-Met-Leu-Phe L-Phenylalanine, N-(N-(N-formyl-L-methionyl)-L-leucyl)- N-Formyl-L-methionyl-L-leucyl-L-phenylalanine N-Formyl-Met-Leu-Phe N-Formylmethionine leucyl-phenylalanine fMLF fMLP (misnomer but widely used) (CAS 59880-97-6)
Why CATO?
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