(2E)-2-{1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-indol-3-yl}-3-(4-chlorophenyl)prop-2-enenitrile CAS 321433-36-7
| CAS No. | 321433-36-7 |
| Molecular Formula | C23H12Cl2F3N3 |
| Molecular Weight | 458.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
(2E)-2-{1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-indol-3-yl}-3-(4-chlorophenyl)prop-2-enenitrile (CAS 321433-36-7) is a high-purity analytical reference standard with the molecular formula C23H12Cl2F3N3 and a molecular weight of 458.26 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution, (2E)-2-{1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-indol-3-yl}-3-(4-chlorophenyl)prop-2-enenitrile is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 458.26 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H12Cl2F3N3 |
| Molecular Weight | 458.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related E Standards
- (2E)-2-{1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-indol-3-yl}-3-(2-chlorophenyl)prop-2-enenitrile (CAS 321433-37-8)
- 4-Chloro-N-{[5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl}-N-(4-methoxyphenyl)benzamide (CAS 956184-23-9)
- 3-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanyl}phenyl)-1-(4-chlorophenyl)urea (CAS 338773-29-8)
- 1-((5-Chloro-1,3-dimethyl-1H-pyrazol-4-yl)sulfonyl)-4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine (CAS 318247-34-6)
- 5-[(1E)-1-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]hydrazin-1-ylidene}ethyl]-1-(4-chlorophenyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione (CAS 321432-27-3)
- Ethyl 3-(2-chloro-6-fluorophenyl)-2-[3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl]propanoate (CAS 477860-54-1)
- 2-(2-(3-(2-(7-Chloro-2-quinolinyl)-ethenylphenyl)-3-hydroxypropyl)phenyl)-2-propanol (CAS 142569-70-8)
- 2,2'-(2-Chloro-2'-fluoro-[1,1'-biphenyl]-3,3'-diyl)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane) (CAS 2374861-97-7)
Recommended Standards
- 2-((5-(2-Bromophenyl)-1,3,4-oxadiazol-2-yl)thio)-N-(2-(trifluoromethyl)phenyl)acetamide (CAS 332170-99-7)
- N-(3,5-Dichloropyridin-4-yl)-2-[1-(4-fluorobenzyl)-5-hydroxy-1H-indol-3-yl]-2-oxo-acetamide (CAS 257892-33-4)
- ({5-(2-bromophenyl)-4-[3-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}thio)acetic acid (CAS 743439-42-1)
- Vinyltriethylsilane(hexafluoroacetylacetonato)silver(I) (CAS 177279-28-6)
- 5-chloro-2-methoxy-4-(1H-pyrrol-1-yl)benzoic acid (CAS 1153234-69-5)
- tert-Butyl 4-(methyl(3-methylpyrazin-2-yl)amino)piperidine-1-carboxylate (CAS 1289388-48-2)
- Tetraethyl [4,4'-bipyridine]-2,2',6,6'-tetracarboxylate (CAS 124558-63-0)
- Tedizolid Impurity 14 (CAS 501939-79-3)
- Posaconazole Impurity 176 (CAS CATO-C4X-1208176)
- 1,7-Dioxaspiro[4.5]decane-2-methanamine (CAS 1870529-68-2)
- 1,1-Difluoro-5-azaspiro[2.5]octane-6-carboxylic acid hydrochloride (CAS 2765270-97-9)
- (R)-2-(1-Ethylpyrrolidin-3-yl)ethanamine (CAS 1412979-05-5)
- 6-Amino-4-((2,4-dichlorophenoxy)methyl)-2-oxo-1-phenyl-1,2-dihydropyrimidine-5-carbonitrile (CAS 338418-69-2)
- Semaglutide impurity 198 (CAS CATO-C4X-2226198)
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