(2E)-3-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]hydrazin-1-yl}-1-[3-(4-fluorophenyl)-2,1-benzoxazol-5-yl]prop-2-en-1-one CAS 321433-59-4
| CAS No. | 321433-59-4 |
| Molecular Formula | C22H13ClF4N4O2 |
| Molecular Weight | 476.81 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 476.81 g/mol gives (2E)-3-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]hydrazin-1-yl}-1-[3-(4-fluorophenyl)-2,1-benzoxazol-5-yl]prop-2-en-1-one distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
(2E)-3-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]hydrazin-1-yl}-1-[3-(4-fluorophenyl)-2,1-benzoxazol-5-yl]prop-2-en-1-one (CAS 321433-59-4), molecular formula C22H13ClF4N4O2 and molecular weight 476.81 g/mol, is a CATO reference standard with documented purity and traceability.
(2E)-3-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]hydrazin-1-yl}-1-[3-(4-fluorophenyl)-2,1-benzoxazol-5-yl]prop-2-en-1-one (C22H13ClF4N4O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H13ClF4N4O2 |
| Molecular Weight | 476.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related E Standards
- N-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)thio)phenyl)-2-(trifluoromethyl)benzamide (CAS 338420-77-2)
- 3-((2-Chloro-6-fluorobenzyl)thio)-5-(((2,6-dichlorobenzyl)thio)methyl)-4-ethyl-4H-1,2,4-triazole (CAS 344271-07-4)
- 5-(2-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)amino)ethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one (CAS 337921-05-8)
- 4-Chloro-2-iodo-5-(trifluoromethyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine (CAS 1420885-94-4)
- (3-Chloro-4-methoxyphenyl)(1-(trifluoromethyl)spiro[benzo[b]pyrrolo[1,2-d][1,4]oxazine-4,4'-piperidin]-1'-yl)methanone (CAS 1433633-45-4)
- N'-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N'-methyl-2,3-diphenylisoxazolidine-5-carbohydrazide (CAS 339102-24-8)
- 1-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)(methyl)amino)-3-(2,6-dichlorobenzyl)-2-methylpyridin-4(1H)-one (CAS 339017-48-0)
- 3-((2-Chloro-6-fluorobenzyl)thio)-1-(3-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile (CAS 685109-30-2)
Recommended Standards
- Ixazomib Impurity 87 (CAS CATO-C4X-126787)
- 2-(2-{[(4-chlorophenyl)sulfanyl]methyl}-1H-1,3-benzodiazol-1-yl)-N-(2,4-dichlorophenyl)acetamide (CAS 339100-94-6)
- Ixazomib Impurity 86 (CAS CATO-C4X-126786)
- 4-(4-Chlorophenyl)-3-((2,6-dichlorobenzyl)thio)-5-(4-methoxyphenyl)-4H-1,2,4-triazole (CAS 476484-40-9)
- Myelin Oligodendrocyte Glycoprotein (35-55) (human) (CAS 163158-19-8)
- 1,2-Diphenyl-1,5,6,7-tetrahydro-4H-indol-4-one (CAS 14073-27-9)
- 2-(1-Aminocyclohexyl)-1h-imidazole-4-carboxylic acid (CAS 1049605-21-1)
- Methyl (3E)-3-(methoxyimino)-2-{[4-(trifluoromethyl)phenyl]formamido}propanoate (CAS 1025366-08-8)
- Methyl 3-Methylpyridine-2-carboxylate (CAS 59718-84-2)
- (2E)-3-(6-Bromo-2H-1,3-benzodioxol-5-yl)-1-[4-(2-fluorophenyl)piperazin-1-yl]prop-2-en-1-one (CAS 478078-33-0)
- 4-methyl-4H-pyran-2,6-dicarboxylic acid (CAS 23046-94-8)
- Proparacaine Impurity 8 HCl (CAS 35288-46-1)
- 5-Hydrazinyl-2-(trifluoromethyl)pyrimidine (CAS 123418-92-8)
- Semaglutide Impurity 131 (CAS 2618647-80-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com