Ixazomib Impurity 86 CAS CATO-C4X-126786
| CAS No. | CATO-C4X-126786 |
| Molecular Formula | C24H34BClN2O5 |
| Molecular Weight | 476.80 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ixazomib Impurity 86 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Ixazomib Impurity 86 (CAS CATO-C4X-126786), a pharmacopoeial impurity reference standard (molecular formula C24H34BClN2O5, MW 476.80 g/mol) used for the identification and quantification of trace impurities in APIs.
Ixazomib Impurity 86 (C24H34BClN2O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H34BClN2O5 |
| Molecular Weight | 476.80 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Ixazomib Standards
- Ixazomib Impurity 87 (CAS CATO-C4X-126787)
- Ixazomib Impurity 46 (CAS CATO-C4X-126746)
- Ixazomib Impurity 47 (CAS CATO-C4X-126747)
- Ixazomib Impurity 48 (CAS CATO-C4X-126748)
- Ixazomib Impurity 20 (CAS CATO-C4X-126720)
- Ixazomib Impurity 35 (CAS CATO-C4X-126735)
- Ixazomib Impurity N1 (CAS 1201903-02-7)
- Ixazomib Impurity 72 (CAS CATO-C4X-126772)
Recommended Standards
- 4,5,6,7-tetrabromo-N,N-dimethyl-1H-benzo[d]imidazol-2-amine (CAS 749234-11-5)
- EUK 124 (CAS 186299-35-4)
- (2E)-3-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]hydrazin-1-yl}-1-[3-(4-fluorophenyl)-2,1-benzoxazol-5-yl]prop-2-en-1-one (CAS 321433-59-4)
- 10E-382S 242472-05-5 5-[4-(4-chlorophenyl)piperazine-1-carbonyl]-1-[(3,4-dichlorophenyl)methyl]-1,2-dihydropyridin-2-one (CAS 242472-05-5)
- Ropinirole Impurity 4 (CAS 120427-93-2)
- Norepinephrine impurity 54 (CAS 1932110-67-2)
- Duloxetine Impurity 18 (CAS 1384080-56-1)
- Neocarrabiose (CAS 6215-96-9)
- 2-Chloro-5-fluorotoluene (CAS 33406-96-1)
- 3-(3-Bromophenyl)-6-chloro-1H-pyrazolo[3,4-d]pyrimidine (CAS 1386399-15-0)
- 2-(Quinolin-8-yl)acetamide (CAS 860204-95-1)
- 5'-Methoxy-N-(naphthalen-2-ylmethyl)-[3,3'-bipyridin]-5-amine (CAS 767342-30-3)
- Cabazitaxel Impurity N1 (CAS 1354900-66-5)
- Tau Peptide (268-282) trifluoroacetate salt (CAS 330456-37-6)
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