Dexchlorpheniramine EP Impurity B CAS 32188-09-3
| CAS No. | 32188-09-3 |
| Molecular Formula | C16H19ClN2 |
| Molecular Weight | 274.79 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Dexchlorpheniramine EP Impurity B (CAS 32188-09-3, C16H19ClN2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Dexchlorpheniramine EP Impurity B (C16H19ClN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Dexchlorpheniramine EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H19ClN2 |
| Molecular Weight | 274.79 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Dexchlorpheniramine Standards
- Dexchlorpheniramine impurity 113 (CAS 694490-86-3)
- Dexchlorpheniramine Impurity 6 (CAS CATO-C4X-16116)
- Dexchlorpheniramine Impurity 8 (CAS CATO-C4X-16118)
- Dexchlorpheniramine Impurity 7 (CAS CATO-C4X-16117)
- Dexchlorpheniramine Impurity 8 (CAS 78539-96-5)
- Dexchlorpheniramine impurity 10 (CAS 19428-44-5)
- Dexchlorpheniramine EP Impurity B Maleate (CAS 23095-76-3)
- Dexchlorpheniramine impurity 12 (CAS 2734416-85-2)
Recommended Standards
- 2-Chloro-N-((1-morpholinocyclohexyl)methyl)acetamide (CAS 900641-08-9)
- S-(2-(4-Chlorophenyl)-2-oxoethyl) O-ethyl carbonodithioate, 97% (CAS 91193-23-6)
- (4-(Tert-butyl)phenyl)(3-chlorophenyl)methanol (CAS 40626-12-8)
- tert-butyl 6-(chloromethyl)-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxylate (CAS 2222756-66-1)
- Vonoprazan Impurity 306 (CAS CATO-C4X-1020306)
- Entacapone impurity 51 (CAS CATO-C4X-162951)
- Ornidazole Impurity 35 (CAS CATO-C4X-133135)
- 3-(3,5-Dimethyl-pyrazol-1-ylmethyl)-4-ethoxy-benzaldehyde (CAS 1011349-26-0)
- 4-(Difluoromethyl)-5-(hydroxymethyl)-6-methoxypyridin-2-ol (CAS 1805452-09-8)
- 3-Bromo-4-methoxy-1-methylquinolin-2(1H)-one (CAS 98751-15-6)
- Methyl 3-Acetoxy-5-amino-4-methoxybenzoate (CAS 838856-87-4)
- (1S,3R)-3-(2-ethylbenzoyl)cyclopentane-1-carboxylic acid (CAS 732252-49-2)
- 3-Fluorobenzimidamide (CAS 69491-64-1)
- Mast Cell Degranulating (MCD) Peptide HR-2 (CAS 80388-04-1)
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