Nicotinic Acid EP Impurity A CAS 3222-47-7
| CAS No. | 3222-47-7 |
| Molecular Formula | C7H7NO2 |
| Molecular Weight | 137.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nicotinic Acid EP Impurity A.
As a process- or degradation-related impurity, Nicotinic Acid EP Impurity A (CAS 3222-47-7, C7H7NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage, Nicotinic Acid EP Impurity A is typically off-white to pale yellow liquid. Its solid-state physicochemical attributes — including a molecular weight of 137.14 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Nicotinic Acid EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H7NO2 |
| Molecular Weight | 137.14 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Nicotinic Standards
- Nicotinic Acid N-Oxide (CAS 2398-81-4)
- Nicotinic Acid-6-Hydroxy (CAS 5006-66-6)
- Nicotinic Acid-13C6,d4 (CAS 1216798-74-1)
- Nicotinic Acid-d4 (CAS 66148-15-0)
- Nicotinic Acid-d3 (major) (CAS 861405-75-6)
- Nicotinic Acid-d1 (CAS 116975-14-5)
- Nicotinic Acid- (CAS 57987-14-1)
- Nicotinic Acid EP Impurity H (CAS 2530-26-9)
Recommended Standards
- Sorafenib Impurity 28 (CAS CATO-C4X-112428)
- 4-methoxynitrobenzene (CAS 1516-21-8)
- Sorafenib Impurity 26 (CAS 1693-39-6)
- Terbutaline impurity 71 (CAS 13262-38-9)
- Salbutamol EP Impurity O TFA salt (CAS 2387728-91-6(Free Base))
- Entecavir Impurity 31 (CAS CATO-C4X-107731)
- Regorafenib Impurity 18 (CAS CATO-C4X-104718)
- 2-(3-(Trifluoromethyl)-5,6,7,8-tetrahydrocyclohepta[c]pyrazol-1(4H)-yl)acetic acid (CAS 695191-63-0)
- 2-(4-Nitrophenoxy)acetaldehyde (CAS 93801-39-9)
- 7-Chloro-N-phenylthiazolo[5,4-d]pyrimidin-2-amine (CAS 871266-78-3)
- 4-Chloro-3-methoxy-5-methylaniline (CAS 940948-34-5)
- 4-Bromo-2-propoxybenzamide (CAS 1228957-02-5)
- (S)-3-Amino-4,4-diphenylbutanoic acid hydrochloride (CAS 332062-01-8)
- Neuropeptide Y (human, rat) trifluoroacetate salt (CAS 90880-35-6)
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