Melphalan Hydrochloride CAS 3223-07-2
| CAS No. | 3223-07-2 |
| Molecular Formula | C13H18Cl2N2O2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 341.66 g/mol gives Melphalan Hydrochloride distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Melphalan Hydrochloride (CAS 3223-07-2), molecular formula C13H18Cl2N2O2HCl and molecular weight 341.66 g/mol, is a CATO reference standard with documented purity and traceability.
Melphalan Hydrochloride (C13H18Cl2N2O2HCl) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H18Cl2N2O2 HCl |
| Molecular Weight | 341.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Melphalan Standards
- Melphalan Isopropyl Ester (CAS 104874-57-9)
- Melphalan Impurity 14 (CAS 1088-80-8)
- Melphalan EP Impurity K (CAS 109-89-7)
- Melphalan-d (CAS 1217854-43-7)
- rac-Melphalan EP Impurity B (CAS 1259994-01-8)
- Melphalan EP Impurity B (CAS 1270153-04-2)
- D-Melphalan (CAS 13045-94-8)
- Melphalan Racemic Mixture (CAS 1465-26-5)
Recommended Standards
- 1-Ethyl-1,2,3,4-tetrahydroquinolin-7-amine hydrochloride (CAS 927684-98-8)
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- (R)-2-Amino-N-(3-(benzyloxy)-1-(1-(methylsulfonyl)spiro[indoline-3,4'-piperidin]-1'-yl)-1-oxopropan-2-yl)-2-methylpropanamide hydrochloride (CAS 159633-92-8)
- 1H-1,2,3-benzotriazole-6-carbaldehyde (CAS 70938-42-0)
- 3,6,9,12,15,18,21,24,27-Nonaoxanonacosanedioic acid (CAS 1432970-26-7)
- 1-methyl-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride (CAS 1240528-50-0)
- 1-Benzoxepine-4-carboxylic acid (CAS 923169-40-8)
- 3-Chloro-2,5-dimethylpyridine (CAS 72093-10-8)
- Tert-butyl (1s,3s)-3-(hydroxymethyl)cyclobutane-1-carboxylate (CAS 2231663-28-6)
- Galanin-Like Peptide (porcine) trifluoroacetate salt (CAS 245114-96-9)
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