Methionine EP Impurity A CAS 3226-65-1
| CAS No. | 3226-65-1 |
| Molecular Formula | C5H11NO3S |
| Molecular Weight | 165.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Methionine EP Impurity A (CAS 3226-65-1, C5H11NO3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, Methionine EP Impurity A is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 165.21 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Methionine EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H11NO3S |
| Molecular Weight | 165.21 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Methionine Standards
- D-Methionine Sulfoxide (CAS 21056-56-4)
- Methionine Impurity 22 (CAS 23631-84-7)
- DL-Methionine D7 (CAS 331665-05-5)
- L-Methionine--13C5,15N (CAS 202468-47-1)
- (±)-Methionine-d4 (CAS 93709-61-6)
- L-Methionine-3,3,4,4 D4 (CAS 67866-75-5)
- L-Methionine-methyl-13C,methyl-d3 73488-65-0 (CAS 73488-65-0)
- D-Methionine-d3 (S-methyl-d3) (CAS 284665-18-5)
Recommended Standards
- Tryptophan Impurity 23 (CAS 62697-73-8)
- Dotinurad Impurity 84 (CAS CATO-C4X-249484)
- Axitinib Impurity 13 (CAS 2527-66-4)
- 2,7-Benzothiazolediamine (CAS 100958-73-4)
- N-Nitroso Venlafaxine EP Impurity D (CAS 2680662-11-5)
- Belumosudil Impurity 47 (CAS 3084112-89-7)
- Metoclopramide Impurity 115 (CAS CATO-C4X-1415115)
- (E)-(Benzyloxy)({1-[3-(2,3-dihydro-1H-isoindol-2-yl)phenyl]ethylidene})amine (CAS 861211-04-3)
- 2-Chlorobenzenesulfonamide (CAS 6961-82-6)
- Tert-butyl (1R,3S,5R)-3-(2-methoxy-2-oxoethyl)-2-azabicyclo[3.1.0]Hexane-2-carboxylate (CAS 2414675-52-6)
- (3-Chloro-4-methoxyphenyl)(1-(trifluoromethyl)spiro[benzo[b]pyrrolo[1,2-d][1,4]oxazine-4,4'-piperidin]-1'-yl)methanone (CAS 1433633-45-4)
- 4,5-Diphenyl-1-(2-propynyl)-1H-imidazol-2-yl 3-fluorobenzyl sulfide (CAS 339277-96-2)
- (3S,4R)-4-(3-fluorophenyl)-1-(2-methoxyethyl)pyrrolidine-3-carboxylic acid (CAS 1824664-85-8)
- Semaglutide impurity 193 (CAS CATO-C4X-2226193)
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