4,4'-Difluoro-[1,1'-biphenyl]-3-amine CAS 323-93-3
| CAS No. | 323-93-3 |
| Molecular Formula | C12H9F2N |
| Molecular Weight | 205.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution, 4,4'-Difluoro-[1,1'-biphenyl]-3-amine is typically pale yellow to yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 205.20 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
4,4'-Difluoro-[1,1'-biphenyl]-3-amine (CAS 323-93-3) is a high-purity analytical reference standard with the molecular formula C12H9F2N and a molecular weight of 205.20 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H9F2N |
| Molecular Weight | 205.20 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoro Standards
- 3',4'-Difluoro-[1,1'-biphenyl]-4-amine (CAS 1184136-90-0)
- 2-(Difluoro-phenyl-methyl)-pyridine (CAS 1204295-90-8)
- 2,6-Difluoro-[1,1'-biphenyl]-4-amine (CAS 1208083-67-3)
- 3',4-Difluoro-[1,1'-biphenyl]-3-amine (CAS 1214339-26-0)
- 4,6-Difluoro-[1,1'-biphenyl]-3-amine (CAS 1214372-76-5)
- 2,4'-Difluoro-[1,1'-biphenyl]-4-amine (CAS 1214374-10-3)
- 2,2-Difluoro-2-(3-fluorophenyl)ethanethioamide (CAS 1334148-20-7)
- 2,2-Difluoro-6-azabicyclo[3.2.2]Nonane-5-carboxylic acid (CAS 1394116-73-4)
Recommended Standards
- 4,4'-Difluoro-[1,1'-biphenyl]-2-amine (CAS 2367-21-7)
- 5,6-difluoro-1H-indole-3-carboxylic acid (CAS 959238-71-2)
- 4-(Trifluoromethyl)benzothioamide (CAS 72505-21-6)
- 5,6-difluoro-1H-indole-7-carboxylic acid (CAS 875305-88-7)
- 1-(2-Bromo-5-methoxypyridin-4-yl)ethanone (CAS 1279816-18-0)
- 6-Ethyl-2-(4-isopropoxyphenyl)quinoline-4-carbonyl chloride (CAS 1160261-06-2)
- 1-(2-Methoxy-4-methylphenyl)ethanone (CAS 35633-35-3)
- 2-Methoxy-6-(4-(trifluoromethyl)phenyl)pyridine (CAS 1202026-99-0)
- Silver hydrogen fluoride (CAS 12249-52-4)
- 2-(2,4-Dimethoxybenzoyl)-6-methoxypyridine (CAS 1187168-15-5)
- Tadalafil Impurity 19 (CAS 6519-67-1)
- Clopidol (CAS 2971-90-6)
- 4-Fluoro-2-nitrophenyl 4-nitrobenzoate (CAS 331459-77-9)
- D-Val23-Tirzepatide (CAS CATO-CPTD788911)
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