Tadalafil Impurity 19 CAS 6519-67-1
| CAS No. | 6519-67-1 |
| Molecular Formula | C13H16N2O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tadalafil Impurity 19.
CATO supplies Tadalafil Impurity 19 (CAS 6519-67-1), a pharmacopoeial impurity reference standard (molecular formula C13H16N2O2HCl, MW 268.74 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Tadalafil Impurity 19 (C13H16N2O2HCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Tadalafil Impurity 19 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C13H16N2O2 HCl |
| Molecular Weight | 268.74 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Tadalafil Standards
- Tadalafil Impurity 10 (CAS 100077-49-4)
- Tadalafil Impurity 75 (CAS 1093940-68-1)
- Tadalafil Impurity 76 (CAS 1093940-70-5)
- Tadalafil Impurity 99 (CAS 114152-23-7)
- Tadalafil Impurity 11 HCl (CAS 1190238-20-0)
- 【禁售不询】Tadalafil Impurity 43 (CAS 120-57-0)
- Tadalafil Impurity N1 (CAS 1220393-12-3)
- Tadalafil Impurity 119 (CAS 130812-44-1)
Recommended Standards
- Esmolol Impurity 64 (CAS CATO-C4X-189164)
- Efinaconazole Impurity 36 (CAS 6965-45-3)
- Etrasimod Impurity 40 (CAS 2863533-12-2)
- tert-Butyl 4-(4-{[(2-Hydroxy-1,1-dimethylethyl)amino]carbonyl}-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate (CAS 1221278-48-3)
- 1,7-Dihydroimidazo[4',5':4,5]benzo[1,2-d][1,2,3]triazol-6-ol (CAS 313527-23-0)
- Tert-butyl (R)-5-amino-8-bromo-1,3,4,5-tetrahydro-2H-benzo[c]azepine-2-carboxylate (CAS 2247616-17-5)
- 1-(4-hydroimidazo[1,2-a]pyridin-7-yl)ethylamine (CAS 1337687-13-4)
- N-[2-(4,4-Difluoropiperidin-1-yl)ethyl]methanesulfonamide (CAS 1823323-31-4)
- 5-Chloro-N,N-dimethylpyrimidin-4-amine (CAS 1849212-30-1)
- Macrophage Inhibitory Peptide (CAS 41961-56-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com