3-Fluorothiophene-2-carboxylic Acid CAS 32431-84-8
| CAS No. | 32431-84-8 |
| Molecular Formula | C5H3FO2S |
| Molecular Weight | 146.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-Fluorothiophene-2-carboxylic Acid.
3-Fluorothiophene-2-carboxylic Acid (CAS 32431-84-8) is a high-purity analytical reference standard with the molecular formula C5H3FO2S and a molecular weight of 146.14 g/mol.
3-Fluorothiophene-2-carboxylic Acid (C5H3FO2S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H3FO2S |
| Molecular Weight | 146.14 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1966 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Fluorothiophene Standards
- 2-Fluorothiophene-3-carboxylic acid (CAS 71154-31-9)
- 4-Fluorothiophene-2-carboxylic Acid (CAS 32431-72-4)
- 4-Fluorothiophene-3-carboxylic acid (CAS 78071-32-6)
- 5-Fluorothiophene-2-carboxamide (CAS 1429418-60-9)
- (E)-5-Fluorothiophene-2-carbaldehyde oxime (CAS 34746-11-7)
- 3-Fluorothiophene-2-carboxamide (CAS 83933-19-1)
- 5-fluorothiophene-2-carboxylic acid (CAS 4377-58-6)
- 5-fluorothiophene-3-carboxylic acid (CAS 32415-50-2)
Recommended Standards
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- 2,3-Dihydro-2,2-dimethyl-2,3-O-(1-isopropylidene)inosine (CAS 136207-52-8)
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