4-Fluorothiophene-3-carboxylic acid CAS 78071-32-6

Description

Compared with other compounds in its class, the molecular weight of 146.14 g/mol gives 4-Fluorothiophene-3-carboxylic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

4-Fluorothiophene-3-carboxylic acid (CAS 78071-32-6), molecular formula C5H3FO2S and molecular weight 146.14 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 4-Fluorothiophene-3-carboxylic acid (C5H3FO2S) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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