1-[2-nitro-4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid CAS 325702-09-8
| CAS No. | 325702-09-8 |
| Molecular Formula | C13H13F3N2O4 |
| Molecular Weight | 318.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-[2-nitro-4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid.
1-[2-nitro-4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid (CAS 325702-09-8) is a high-purity analytical reference standard with the molecular formula C13H13F3N2O4 and a molecular weight of 318.25 g/mol.
The molecular framework of 1-[2-nitro-4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid (C13H13F3N2O4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-[2-nitro-4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H13F3N2O4 |
| Molecular Weight | 318.25 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related nitro Standards
- 1-(4-Nitro-2-(trifluoromethyl)phenyl)piperidine-3-carboxylic acid (CAS 1171918-77-6)
- 1-[2-Nitro-4-(trifluoromethyl)phenyl]piperidine-2-carboxylic acid (CAS 1219146-99-2)
- 1-(4-Nitro-3-(trifluoromethyl)phenyl)piperidine-3-carboxylic acid (CAS 942474-46-6)
- 1-[2-nitro-4-(trifluoromethyl)phenyl]piperidine-4-carboxylic acid (CAS 325702-10-1)
- 3-Nitro-2-(quinolin-2-yl)-4H-chromen-4-one (CAS 88685-90-9)
- 4-(4-Nitro-1,3-dioxoisoindolin-2-yl)cyclohexane-1-carboxylic acid (CAS 432537-75-2)
- 5-Methyl-9-nitro-11-oxo-5,11-dihydrobenzo[4,5]imidazo[1,2-b]isoquinoline-6-carbonitrile (CAS 128505-80-6)
- N-(6-nitro-2-oxo-2H-chromen-3-yl)heptanamide (CAS 852-32-4)
Recommended Standards
- 1-(2,4-Difluorophenyl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxylic acid (CAS 618102-77-5)
- 2-(4-(Trifluoromethoxy)benzylidene)-1H-indene-1,3(2H)-dione (CAS 940827-39-4)
- (E)-2,2,2-trifluoro-N-(3-(hydroxyimino)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-yl)acetamide (CAS 861209-51-0)
- 4-(5-(4-(Trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)benzaldehyde (CAS 480391-18-2)
- N1-(2-Methoxyethyl)-N2-((3-(thiophen-2-ylsulfonyl)-1,3-oxazinan-2-yl)methyl)oxalamide (CAS 869072-05-9)
- Methyl 4-bromo-5-sulfamoylthiophene-2-carboxylate (CAS 2137611-69-7)
- Methyl 6-(pent-1-yn-1-yl)pyridazine-3-carboxylate (CAS 89967-27-1)
- Methyl 2-amino-2-(2-fluorophenyl)propanoate (CAS 763914-43-8)
- 1-(3-(Trifluoromethyl)phenyl)-1H-pyrrole-2-carboxylic acid (CAS 233692-71-2)
- 3-(1-((tert-Butoxycarbonyl)amino)ethyl)benzoic acid (CAS 165949-84-8)
- 7-Nitro-1,2,3,4-tetrahydroquinoline (CAS 30450-62-5)
- 2-Benzyl-octahydrocyclopenta[c]pyrrol-4-amine (CAS 186201-60-5)
- 2-(5-(Pyridin-3-yl)-1,2,4-oxadiazol-3-yl)ethan-1-amine (CAS 946745-15-9)
- Semaglutide impurity 84 (CAS CATO-C4X-222684)
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