Etoricoxib Impurity 24 CAS 325855-71-8
| CAS No. | 325855-71-8 |
| Molecular Formula | C18H15ClN2O3S |
| Molecular Weight | 374.84 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Etoricoxib Impurity 24 (CAS 325855-71-8) is a certified pharmaceutical impurity reference standard with the molecular formula C18H15ClN2O3S and a molecular weight of 374.84 g/mol.
The molecular framework of Etoricoxib Impurity 24 (C18H15ClN2O3S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Etoricoxib Impurity 24 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H15ClN2O3S |
| Molecular Weight | 374.84 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Etoricoxib Standards
- Etoricoxib Impurity 10 (CAS 349536-41-0)
- Etoricoxib Impurity 1 (CAS 325855-74-1)
- Etoricoxib Impurity 10 (CAS 646459-45-2)
- Etoricoxib Impurity 85 (CAS CATO-C4X-108085)
- Etoricoxib Impurity 26 (CAS CATO-C4X-108026)
- Etoricoxib Impurity 34 (CAS CATO-C4X-108034)
- Etoricoxib Impurity 8 (CAS 646459-39-4)
- Etoricoxib D4 (CAS 1131345-14-6)
Recommended Standards
- Etizolam Impurity 29 (CAS CATO-C4X-350929)
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- 2-((4-Amino-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-chloro-2-methylphenyl)acetamide (CAS 577990-13-7)
- Dorzagliatin Impurity 7 (CAS CATO-C4X-34417)
- Mivacurium Chloride Impurity 1 (CAS 733704-04-6)
- Ibrutinib Impurity N21 (CAS 2540665-98-1)
- 3,4-Dichloroaniline-d2 (CAS 1219803-22-1)
- Ethylenediaminetetraacetic acid (trisodium hydrate) (CAS 10378-22-0)
- 5-(4-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)-5H-thieno[2,3-c]pyrrole (CAS 338781-10-5)
- 4-(5-(Trifluoromethyl)isoxazol-3-yl)aniline (CAS 2241144-76-1)
- 2-((Isopropylamino)methyl)pyrimidin-4-amine (CAS 1339435-65-2)
- 5-Bromo-N-(2-methoxyethyl)furan-2-carboxamide (CAS 545427-40-5)
- Semaglutide impurity 56 (CAS CATO-C4X-222656)
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