Etoricoxib Impurity 10 CAS 646459-45-2
| CAS No. | 646459-45-2 |
| Molecular Formula | C19H17ClN2O2S |
| Molecular Weight | 372.87 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Etoricoxib Impurity 10.
Etoricoxib Impurity 10 (CAS 646459-45-2) is a certified pharmaceutical impurity reference standard with the molecular formula C19H17ClN2O2S and a molecular weight of 372.87 g/mol.
Owing to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution, Etoricoxib Impurity 10 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 372.87 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H17ClN2O2S |
| Molecular Weight | 372.87 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Etoricoxib Standards
- Etoricoxib Impurity 10 (CAS 349536-41-0)
- Etoricoxib Impurity 1 (CAS 325855-74-1)
- Etoricoxib Impurity 24 (CAS 325855-71-8)
- Etoricoxib Impurity 85 (CAS CATO-C4X-108085)
- Etoricoxib Impurity 26 (CAS CATO-C4X-108026)
- Etoricoxib Impurity 34 (CAS CATO-C4X-108034)
- Etoricoxib Impurity 8 (CAS 646459-39-4)
- Etoricoxib D4 (CAS 1131345-14-6)
Recommended Standards
- N-(2-((2-(4-chlorophenyl)-4-methylthiazol-5-yl)methoxy)phenyl)acetamide (CAS 866018-32-8)
- Dasatinib impurity 60 (CAS CATO-C4X-160760)
- N-((2-(4-chlorophenyl)-4-methylthiazol-5-yl)methyl)-3-methoxybenzamide (CAS 865658-31-7)
- 1,3-Dibromo-2-(3-bromopropoxy)benzene (CAS 206347-33-3)
- Cephalexin Impurity 20 (CAS CATO-C4X-126120)
- Sivelestat sodium Impurity 3 (CAS 155023-59-9)
- Perampanel Impurity 1 (CAS 381248-06-2)
- 2-[(2-Aminoethyl)amino]pyridine-4-carboxylic acid (CAS 766544-99-4)
- 3-(4-Chlorophenyl)-5-(cinnamylthio)-4H-1,2,4-triazol-4-amine (CAS 577768-60-6)
- 6-Bromoisoquinoline-1-carbonitrile (CAS 1082674-24-5)
- Methyl 3-(2,4-Dichlorophenyl)-3-oxopropanoate (CAS 56719-67-6)
- 6-fluoroquinazoline-4-carboxylic acid (CAS 1781315-63-6)
- (5-(1,3-Dioxolan-2-yl)thiophen-2-yl)(2,4-dimethylphenyl)methanone (CAS 898779-19-6)
- Semaglutide impurity 54 (CAS CATO-C4X-222654)
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