4-(2,5-Dichloro-3-thienyl)-1,3-thiazol-2-amine CAS 325988-82-7
| CAS No. | 325988-82-7 |
| Molecular Formula | C7H4Cl2N2S2 |
| Molecular Weight | 251.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4-(2,5-Dichloro-3-thienyl)-1,3-thiazol-2-amine (C7H4Cl2N2S2) is characterized by a nitrile group, sulfur-containing functionality, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
4-(2,5-Dichloro-3-thienyl)-1,3-thiazol-2-amine (CAS 325988-82-7), molecular formula C7H4Cl2N2S2 and molecular weight 251.16 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H4Cl2N2S2 |
| Molecular Weight | 251.16 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 2 |
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- 3-(Bromomethyl)-8-chloro-6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine (CAS 1616500-70-9)
- 2-(1,5-Dimethyl-1h-pyrazol-4-yl)quinoline-4-carboxylic acid (CAS 925145-52-4)
- 2-Chloro-5-(1-isopropylpiperidin-2-yl)-4-methylpyridine (CAS 1352538-22-7)
- Etomidate Impurity 32（Mixture of Diastereoisomer） (CAS CATO-C4X-188432)
- (2-chlorothiazol-5-yl)methanamine (CAS 120740-08-1)
- n-(3-Iodophenyl)tetrahydro-2h-pyran-4-amine (CAS 179943-23-8)
- 6-Propylpyrrolo[1,2-a]pyrimidine (CAS 334026-52-7)
- Exenatide Acetate (CAS 141732-76-5)
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