1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-3-(o-tolyl)thiourea CAS 326815-30-9
| CAS No. | 326815-30-9 |
| Molecular Formula | C14H11ClF3N3S |
| Molecular Weight | 345.77 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-3-(o-tolyl)thiourea is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-3-(o-tolyl)thiourea (CAS 326815-30-9) is a high-purity analytical reference standard with the molecular formula C14H11ClF3N3S and a molecular weight of 345.77 g/mol.
The molecular framework of 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-3-(o-tolyl)thiourea (C14H11ClF3N3S) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-3-(o-tolyl)thiourea under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H11ClF3N3S |
| Molecular Weight | 345.77 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
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Recommended Standards
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- 2-((4-Chlorophenyl)thio)-N-(4-(trifluoromethyl)phenyl)acetamide (CAS 746613-17-2)
- Indoxacarb Impurity 2 (CAS 135656-94-9)
- 2-Methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carbohydrazide (CAS 844891-24-3)
- 1-methoxy-4,4-dimethylpentan-2-one (CAS 1314923-03-9)
- (1R,3R)-3-methoxycyclohexan-1-amine hydrochloride (CAS 1067908-49-9)
- 9-Butyl-8-((3-methoxyphenyl)sulfinyl)-9H-purin-6-amine (CAS 827302-56-7)
- 1-(5-Amino-1-methyl-3-indolyl)ethanone (CAS 634182-57-3)
- (E)-3-(4-isopropylphenyl)-4-methylpent-2-enoic acid (CAS 1017328-19-6)
- 5-Bromo-2-(3-(methylsulfonyl)azetidin-1-yl)pyrimidine (CAS 2126664-49-9)
- 2-Methyl-1-(5-methylfuran-2-yl)propan-1-amine (CAS 926263-80-1)
- cis-1-Boc-4-(mesyloxy)-L-proline ethyl ester (CAS 149055-71-0)
- Semaglutide Impurity 149 (CAS CATO-C4X-2226149)
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