6-(Trifluoromethyl)-1H-indole-2-carboxylic acid CAS 327-20-8
| CAS No. | 327-20-8 |
| Molecular Formula | C10H6F3NO2 |
| Molecular Weight | 229.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 6-(Trifluoromethyl)-1H-indole-2-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies 6-(Trifluoromethyl)-1H-indole-2-carboxylic acid (CAS 327-20-8), a certified reference material (molecular formula C10H6F3NO2, MW 229.16 g/mol) for analytical method development and quality control.
The molecular framework of 6-(Trifluoromethyl)-1H-indole-2-carboxylic acid (C10H6F3NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H6F3NO2 |
| Molecular Weight | 229.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluoromethyl Standards
- 2-Methyl-8-(trifluoromethyl)-4H-benzo[d][1,3]oxazin-4-one (CAS 1044749-60-1)
- 3-(5-(Trifluoromethyl)-1,3,4-oxadiazol-2-yl)aniline (CAS 1197229-53-0)
- 1-(4-(Trifluoromethyl)pyrimidin-2-yl)-1H-pyrazol-4-amine (CAS 1210732-94-7)
- 4-(3-(Trifluoromethyl)-3H-diazirin-3-yl)benzamide (CAS 1216997-96-4)
- 1-[5-(trifluoromethyl)pyridin-2-yl]-1h-1,2,4-triazol-5-amine (CAS 1249569-04-7)
- 3-(4-(Trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-amine (CAS 1260886-71-2)
- 6-(Trifluoromethyl)-1H-indole-4-carboxylic acid (CAS 1352896-61-7)
- 6-(Trifluoromethyl)-1H-indole-3-carboxylic acid (CAS 13544-10-0)
Recommended Standards
- 6-(Trifluoromethoxy)quinolin-2(1H)-one (CAS 676131-27-4)
- 6-(Trifluoromethyl)-1H-indole-5-carboxylic acid (CAS 2091850-39-2)
- 6-(Trifluoromethoxy)isoquinolin-1(2H)-one (CAS 630423-43-7)
- 6-(Trifluoromethyl)isoquinoline-1,3(2H,4H)-dione (CAS 501130-54-7)
- 6-Chloro-3-methyl-1-benzothiophene-2-sulfonyl chloride (CAS 752135-37-8)
- (s)-5-Fluoro-2-(pyrrolidin-3-yl)isoindolin-1-one hydrochloride (CAS 1786969-20-7)
- (3-Ethynylphenyl)methanamine hydrochloride (CAS 1162257-52-4)
- 4-(Difluoromethyl)-2-isopropyl-2h-pyrazolo[3,4-b]pyridin-6-ol (CAS 1018126-31-2)
- N-(2-(4-Nitrophenoxy)ethyl)cyclopropanamine (CAS 1033201-53-4)
- 3-Cyclopropyl-2-(4-fluorophenyl)-3-oxopropanenitrile (CAS 1094321-38-6)
- Ethyl 4-chloro-1H-imidazole-2-carboxylate (CAS 1824094-92-9)
- Dimethyl 2-methoxypyrimidine-4,5-dicarboxylate (CAS 143034-61-1)
- 1-(4-Bromo-2-methylbenzoyl)-4-piperidinone (CAS 1157019-81-2)
- (Leu31,Pro34)-Peptide YY (human) trifluoroacetate salt (CAS 179986-95-9)
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