3-(3-Trifluoromethyl-phenylsulfamoyl)-benzoic acid CAS 327092-91-1
| CAS No. | 327092-91-1 |
| Molecular Formula | C14H10F3NO4S |
| Molecular Weight | 345.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-(3-Trifluoromethyl-phenylsulfamoyl)-benzoic acid.
CATO supplies 3-(3-Trifluoromethyl-phenylsulfamoyl)-benzoic acid (CAS 327092-91-1), a certified reference material (molecular formula C14H10F3NO4S, MW 345.29 g/mol) for analytical method development and quality control.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution, 3-(3-Trifluoromethyl-phenylsulfamoyl)-benzoic acid is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 345.29 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H10F3NO4S |
| Molecular Weight | 345.29 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Trifluoromethyl Standards
- 2-[3-(Trifluoromethyl)phenylsulfonamido]benzoic Acid (CAS 306955-85-1)
- 3-((3-(Trifluoromethyl)phenyl)sulfonamido)benzoic acid (CAS 613657-60-6)
- 4-((3-(Trifluoromethyl)phenyl)sulfonamido)benzoic acid (CAS 613657-61-7)
- 4-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)benzoic acid (CAS 321979-21-9)
- N'-(6-(trifluoromethyl)nicotinoyl)benzenesulfonohydrazide (CAS 1092346-06-9)
- 3-Phenyl-4-[({[3-(trifluoromethyl)phenyl]methyl}amino)methylidene]-4,5-dihydro-1H-pyrazol-5-one (CAS 477850-66-1)
- 5-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}-1,3-thiazolidine-2,4-dione (CAS 866151-49-7)
- 3-[3,5-di(trifluoromethyl)phenyl]prop-2-ynyl 2-chloroacetate (CAS 680579-65-1)
Recommended Standards
- 3-Nitro-2-((1-(3-nitropyridin-2-yl)-1H-1,2,4-triazol-3-yl)thio)pyridine (CAS 251307-22-9)
- 2-(Benzylsulfonyl)-1-nitro-4-(trifluoromethyl)benzene (CAS 866137-59-9)
- 4-(2,3,4-Trifluorobenzenesulfonamidomethyl)benzoic acid (CAS 794559-15-2)
- (5-((3,5-Dichlorophenyl)thio)-1-ethyl-4-isopropyl-1H-imidazol-2-yl)methanol (CAS 178979-14-1)
- (4-(cyclopropylmethyl)morpholin-2-yl)methanamine dihydrochloride (CAS 141815-15-8)
- 3-Amino-N-(2-methylphenyl)benzenesulfonamide (CAS 847171-68-0)
- 2-mercapto-3-(3-methoxyphenyl)-3,5-dihydro-4H-imidazol-4-one (CAS 72799-35-0)
- 4-Amino-7-methylpteridine 5-oxide (CAS 1010-55-5)
- tert-Butyl 4-(2-ethoxy-2-oxo-1-phenylethyl)-4-(nitromethyl)piperidine-1-carboxylate (CAS 1245643-40-6)
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- Insulin Glulisine (CAS 207748-29-6)
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