3-Hydroxy-5-(trifluoromethyl)benzoic acid CAS 328-69-8
| CAS No. | 328-69-8 |
| Molecular Formula | C8H5F3O3 |
| Molecular Weight | 206.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-Hydroxy-5-(trifluoromethyl)benzoic acid.
3-Hydroxy-5-(trifluoromethyl)benzoic acid (CAS 328-69-8) is a high-purity analytical reference standard with the molecular formula C8H5F3O3 and a molecular weight of 206.12 g/mol.
3-Hydroxy-5-(trifluoromethyl)benzoic acid (C8H5F3O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 3-Hydroxy-5-(trifluoromethyl)benzoic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H5F3O3 |
| Molecular Weight | 206.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Hydroxy Standards
- 4-Hydroxy-2-(trifluoromethoxy)benzaldehyde (CAS 1017083-37-2)
- 2-Hydroxy-4-(trifluoromethoxy)benzaldehyde (CAS 1071156-25-6)
- 2-Hydroxy-6-(trifluoromethyl)nicotinamide (CAS 116548-03-9)
- 3-Hydroxy-4-(trifluoromethoxy)benzaldehyde (CAS 1208078-41-4)
- 2-Hydroxy-2-(2,3,4-trifluorophenyl)acetic acid (CAS 1214332-27-0)
- 5-Hydroxy-2-(trifluoromethyl)benzoic acid (CAS 1243373-31-0)
- 2-Hydroxy-6-(trifluoromethoxy)benzaldehyde (CAS 1261500-70-2)
- 5-Hydroxy-2-(trifluoromethoxy)benzaldehyde (CAS 1261584-14-8)
Recommended Standards
- 3-Hydroxy-2-(trifluoromethyl)benzoic acid (CAS 4563-94-4)
- 3-Methyl-5-nitro-2-(trifluoromethyl)pyridine (CAS 941606-49-1)
- 3-Fluoro-N,N-dimethyl-4-(phenyldiazenyl)aniline (CAS 326-16-9)
- 3-Nitro-4-(trifluoromethyl)aniline (CAS 393-80-6)
- 5,7-Dimethyl-3H-imidazo[4,5-b]pyridin-2-amine (CAS 132898-05-6)
- 1-N-(4-methylphenyl)benzene-1,2-diamine (CAS 91806-09-6)
- 2-(Aminomethyl)-3-chloro-4-(difluoromethyl)-5-fluoropyridine (CAS 1805985-17-4)
- 5-Acetyl-2-(benzylamino)-6-methylpyridine-3-carbonitrile (CAS 303146-80-7)
- 2-(Methoxymethyl)tetrahydro-2H-pyran-2-carbaldehyde (CAS 2138083-57-3)
- 1-(3-Nitrophenyl)-4-(3-(trifluoromethyl)phenyl)-1H-pyrazol-5-amine (CAS 324008-96-0)
- 3-Chloro-3,4,4-trifluorobenzophenone (CAS 951890-28-1)
- N-(4-amino-2-methoxyphenyl)tetrahydro-2H-pyran-4-carboxamide (CAS 1220019-99-7)
- 3-Chloro-[1,1'-biphenyl]-4-carbaldehyde (CAS 79213-60-8)
- Liraglutide Impurity 21 TFA Salt (CAS CATO-C4X-199221)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com