2-Hydroxy-3-nitro-5-(trifluoromethyl)pyridine CAS 33252-64-1
| CAS No. | 33252-64-1 |
| Molecular Formula | C6H3F3N2O3 |
| Molecular Weight | 208.09 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Hydroxy-3-nitro-5-(trifluoromethyl)pyridine.
CATO supplies 2-Hydroxy-3-nitro-5-(trifluoromethyl)pyridine (CAS 33252-64-1), a certified reference material (molecular formula C6H3F3N2O3, MW 208.09 g/mol) for analytical method development and quality control.
Structurally, 2-Hydroxy-3-nitro-5-(trifluoromethyl)pyridine (C6H3F3N2O3) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 208.09 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H3F3N2O3 |
| Molecular Weight | 208.09 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Hydroxy Standards
- 2-Hydroxy-5-nitro-3-(trifluoromethyl)pyridine (CAS 99368-66-8)
- N-Hydroxy-4-nitrophthalimide (CAS 105969-98-0)
- N'-Hydroxy-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboximidamide (CAS 1359996-85-2)
- Ethyl 7-hydroxy-[1,2,3]triazolo[1,5-a]pyrimidine-3-carboxylate (CAS 1352723-55-7)
- 2-(5-Hydroxy-3-oxo-1,3-dihydroisobenzofuran-1-yl)acetic acid (CAS 144402-59-5)
- 4-((5-Hydroxy-3-methylisoxazol-4-yl)methylene)-3-methylisoxazol-5(4H)-one (CAS 14532-32-2)
- Methyl (4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-2-yl)carbamate (CAS 1598381-27-1)
- (3Z)-4-Hydroxy-4-(3-hydroxyphenyl)-2-oxobut-3-enoic acid (CAS 904814-38-6)
Recommended Standards
- 2,2,2-Trifluoro-1-(4-nitro-1H-pyrrol-2-yl)-ethanone (CAS 841243-46-7)
- 6-Oxo-2-(trifluoromethyl)-1,6-dihydropyrimidine-5-carboxylic acid (CAS 188781-49-9)
- Dichlormid (CAS 37764-25-3)
- 3-Nitro-5-(trifluoromethyl)pyridin-2(3H)-one (CAS 1851650-55-9)
- (R)-3-(4-Isopropylphenyl)piperazin-2-one (CAS 1228569-23-0)
- 3'-Bromo-2-ethoxy-1,1'-biphenyl (CAS 1443309-63-4)
- 2-(((Benzyloxy)carbonyl)amino)-3-(phenylthio)propanoic acid (CAS 82611-65-2)
- 4-(5-Bromo-2-thienyl)thiazol-2-amine (CAS 34801-14-4)
- 5-(chloromethyl)-2-methyl-thiazole (CAS 63140-11-4)
- tert-Butyl (4-chlorocyclohexyl)carbamate (CAS 35426-68-7)
- Sodium (Z)-1-cyanoprop-1-en-2-olate (CAS 1199252-10-2)
- 2-(Difluoromethyl)-3-fluoroaniline (CAS 2091605-37-5)
- 5-bromo-4-cyano-2-fluorobenzene-1-sulfonyl chloride (CAS 1803562-48-2)
- Semaglutide (CAS CATO-C4X-2226105)
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