2-Hydroxy-5-(Trifluoromethyl)Pyridine CAS 33252-63-0
| CAS No. | 33252-63-0 |
| Molecular Formula | C6H4F3NO |
| Molecular Weight | 163.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-Hydroxy-5-(Trifluoromethyl)Pyridine is closely related to an amide group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 2-Hydroxy-5-(Trifluoromethyl)Pyridine (CAS 33252-63-0), a certified reference material (molecular formula C6H4F3NO, MW 163.10 g/mol) for analytical method development and quality control.
The molecular framework of 2-Hydroxy-5-(Trifluoromethyl)Pyridine (C6H4F3NO) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-Hydroxy-5-(Trifluoromethyl)Pyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H4F3NO |
| Molecular Weight | 163.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Hydroxy Standards
- 4-Hydroxy-2-(trifluoromethyl)pyridine (CAS 170886-13-2)
- 3-Hydroxy-5-(trifluoromethyl)pyridine (CAS 186593-14-6)
- 2-Hydroxy-6-trifluoromethylpyridine (CAS 34486-06-1)
- 9-Hydroxy-4H-pyrimido[1,6-a]pyrimidin-4-one (CAS 123420-39-3)
- 4-Hydroxy-5H-cyclohepta[d]isoxazol-5-one (CAS 178315-30-5)
- 4-hydroxy-2,3-dihydro-1H-isoindole-1,3-dione (CAS 41709-87-9)
- 4-Hydroxy-2H-pyrano[3,2-b]pyridin-2-one (CAS 55502-23-3)
- (Z)-4-Hydroxy-4-(pyridin-2-yl)but-3-en-2-one (CAS 1031694-63-9)
Recommended Standards
- Diethyl Cyanophosphonate (CAS 2942-58-7)
- 6-Trifluoromethyl-pyrazin-2-ylamine (CAS 69816-35-9)
- 3-Ethoxy-2-fluoro-2-methyl-3-oxopropanoic acid (CAS 100701-51-7)
- 6-(Trifluoromethyl)pyridin-3-ol (CAS 216766-12-0)
- 6-N-(furan-2-ylmethyl)-2-N-methyl-7H-purine-2,6-diamine (CAS 1772864-09-1)
- 8-Bromo-6-chloro-3,4-dihydro-2H-benzo[b][1,4]oxazine (CAS 625394-67-4)
- 2-Chloro-4-cyanobenzenesulfonamide (CAS 34263-52-0)
- N-(3-nitrophenyl)decanamide (CAS 72298-61-4)
- 4-Chloroquinazoline-2-carboxylic acid (CAS 944902-14-1)
- benzyl (3S,4S)-3-azido-4-hydroxy-pyrrolidine-1-carboxylate (CAS 799767-83-2)
- 4-Fluoro-N-(2-hydroxyethyl)benzenesulfonamide (CAS 383-49-3)
- 4-Bromo-2-nitrophenyl 2-(2-piperidinyl)ethylether hydrochloride (CAS 1219964-60-9)
- 1-Chloro-4-(3,4-dichlorophenyl)phthalazine (CAS 121004-95-3)
- Semaglutide Impurity 12 (CAS CATO-C4X-222612)
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