Lidocaine Impurity N4 CAS 332903-68-1
| CAS No. | 332903-68-1 |
| Molecular Formula | C16H12ClF4NO |
| Molecular Weight | 345.72 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Lidocaine Impurity N4 (C16H12ClF4NO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Lidocaine Impurity N4 (CAS 332903-68-1) is a certified pharmaceutical impurity reference standard with the molecular formula C16H12ClF4NO and a molecular weight of 345.72 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Lidocaine Impurity N4 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H12ClF4NO |
| Molecular Weight | 345.72 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Lidocaine Standards
- Lidocaine impurity 58 (CAS CATO-C4X-167958)
- Lidocaine EP Impurity E (CAS 745798-07-6)
- Lidocaine Impurity 72 (CAS CATO-C4X-167972)
- Lidocaine Impurity 31 (CAS 70336-49-1)
- Lidocaine Impurity 81 (CAS CATO-C4X-167981)
- Lidocaine Impurity 101 (CAS CATO-C4X-1679101)
- Lidocaine Impurity 93 (CAS CATO-C4X-167993)
- Lidocaine Impurity 100 (CAS CATO-C4X-1679100)
Recommended Standards
- 3-Chloro-7-{[(dimethylamino)(ethoxy)phosphoryl]oxy}-4-methyl-2H-chromen-2-one (CAS 194988-29-9)
- 4-[4-chloro-3-(trifluoromethyl)benzenesulfonamido]butanoic acid (CAS 612043-44-4)
- Triphenylselenium chloride (CAS 17166-13-1)
- Methyl N-[4-chloro-3-(trifluoromethyl)phenyl]-N-(methylsulfonyl)glycinate (CAS 333446-72-3)
- Fudosteine impurity 74 (CAS CATO-C4X-144774)
- Adapalene impurity 19 (CAS 726-94-3)
- Calcipotriol Impurity 20 (CAS 127516-23-8)
- 4-Ethyl-2-methylphenol (CAS 2219-73-0)
- 2-Amino-N-(pyridin-3-ylmethyl)benzamide hydrochloride (CAS 1245569-04-3)
- 6-Bromo-2,3-dihydropyrazolo[5,1-b]oxazole (CAS 1934827-75-4)
- 1-(4-Bromopyridin-2-yl)ethan-1-amine (CAS 1270432-26-2)
- Bis[(2-dimethylamino)phenyl]amine nickel(II) chloride (CAS 1033772-47-2)
- (S)-1-Benzyl 4-methyl 2-((tert-butoxycarbonyl)amino)succinate (CAS 158201-15-1)
- (Leu31,Pro34)-Peptide YY (human) trifluoroacetate salt (CAS 179986-95-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com