N-(3-Chloro-2-methylphenyl)-2-((2-phenylquinazolin-4-yl)thio)acetamide CAS 332914-46-2
| CAS No. | 332914-46-2 |
| Molecular Formula | C23H18ClN3OS |
| Molecular Weight | 419.93 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
N-(3-Chloro-2-methylphenyl)-2-((2-phenylquinazolin-4-yl)thio)acetamide (CAS 332914-46-2), molecular formula C23H18ClN3OS and molecular weight 419.93 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of N-(3-Chloro-2-methylphenyl)-2-((2-phenylquinazolin-4-yl)thio)acetamide (C23H18ClN3OS) is characterized by a steroid core, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-(3-Chloro-2-methylphenyl)-2-((2-phenylquinazolin-4-yl)thio)acetamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H18ClN3OS |
| Molecular Weight | 419.93 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
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Recommended Standards
- 6-(4-Chlorophenyl)-2-(3-(2,5-dimethyl-1H-pyrrol-1-yl)thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine (CAS 691869-95-1)
- 2-(Difluoromethyl)-4,6-diiodopyridine-3-acetonitrile (CAS 1805254-12-9)
- 6-(3-Chlorophenyl)-2-[3-(2,5-dimethyl-1H-pyrrol-1-yl)thiophen-2-yl]pyrazolo[1,5-a]pyrimidin-7-amine (CAS 383147-74-8)
- 2-(Difluoromethyl)-3,5-diiodopyridine-6-acetonitrile (CAS 1805322-69-3)
- 6-Bromo-1H-pyrido[2,3-d][1,3]oxazine-2,4-dione (CAS 1112208-70-4)
- (3AR,4R,9S,9aS,9bR)-9-(methoxymethoxy)-2,2-dimethyloctahydro[1,3]dioxolo[4,5-g]indolizin-4-ol (CAS 160727-35-5)
- 2-(Chloromethyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine (CAS 118000-42-3)
- 1-Methyl-5-(trifluoromethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione (CAS 21579-18-0)
- Thiepane-3,6-diol (CAS 7458-10-8)
- N,N-Dimethyl-3-butyl-1H-indene-2-ethanamine-d9 Hydrobromide (CAS 1346604-86-1)
- Arenobufagin 3-hemisuberate (CAS 30219-16-0)
- N-cyclopropyl-3,5-dimethylisoxazole-4-carboxamide (CAS 925615-76-5)
- 1-(3-Fluoro-5-methylphenyl)propan-2-one (CAS 1532899-14-1)
- Tirzepatide Impurity 13 (CAS CATO-C4X-324013)
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