Hydrocortisone Impurity N1 CAS 3331-69-9
| CAS No. | 3331-69-9 |
| Molecular Formula | C25H34O7 |
| Molecular Weight | 446.53 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Hydrocortisone Impurity N1 (CAS 3331-69-9) is a certified pharmaceutical impurity reference standard with the molecular formula C25H34O7 and a molecular weight of 446.53 g/mol.
Hydrocortisone Impurity N1 (C25H34O7) contains a flavonoid core, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Hydrocortisone Impurity N1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H34O7 |
| Molecular Weight | 446.53 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Hydrocortisone Standards
- Hydrocortisone Acetate EP Impurity G (CAS 81968-66-3)
- Hydrocortisone Impurity D (Na) (CAS 70795-33-4)
- Hydrocortisone Impurity N2 (CAS 13609-63-7)
- Hydrocortisone-21-valerate (CAS 6678-00-8)
- Hydrocortisone Impurity 59 (CAS CATO-C4X-140159)
- Hydrocortisone 17-Valerate (CAS 57524-89-7)
- Hydrocortisone Impurity 72 (CAS CATO-C4X-140172)
- Hydrocortisone 21-phosphate (CAS 3863-59-0)
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