Hydrocortisone 21-phosphate CAS 3863-59-0
| CAS No. | 3863-59-0 |
| Molecular Formula | C21H31O8P |
| Molecular Weight | 442.44 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 442.44 g/mol gives Hydrocortisone 21-phosphate distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Hydrocortisone 21-phosphate (CAS 3863-59-0) is a high-purity analytical reference standard with the molecular formula C21H31O8P and a molecular weight of 442.44 g/mol.
Hydrocortisone 21-phosphate (C21H31O8P) contains a phosphate ester group, a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H31O8P |
| Molecular Weight | 442.44 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
Related Hydrocortisone Standards
- Hydrocortisone Impurity 72 (CAS CATO-C4X-140172)
- Hydrocortisone Acetate EP Impurity G (CAS 81968-66-3)
- Hydrocortisone Impurity N1 (CAS 3331-69-9)
- Hydrocortisone Impurity D (Na) (CAS 70795-33-4)
- Hydrocortisone Impurity N2 (CAS 13609-63-7)
- Hydrocortisone-21-valerate (CAS 6678-00-8)
- Hydrocortisone Impurity 59 (CAS CATO-C4X-140159)
- Hydrocortisone 17-Valerate (CAS 57524-89-7)
Recommended Standards
- Bis(4-dibenzofuranyl)phenylphosphine (CAS 52379-39-2)
- Prednisolone EP Impurity A Hydrochloride (CAS 393782-60-0)
- Bis(2-dibenzofuranyl)phenylphosphine (CAS 230310-67-5)
- Tris(2,4-dimethoxyphenyl)phosphane (CAS 95704-29-3)
- 2-(Azepan-1-yl)pyrimidine-5-carbaldehyde (CAS 1339348-75-2)
- (R)-2-(4-Chlorophenyl)morpholine hydrochloride (CAS 1820572-03-9)
- Methyl cyclododecanecarboxylate (CAS 1855-59-0)
- 4-Benzoyltetrahydro-2H-pyran-4-carbonitrile (CAS 1403567-06-5)
- 3-Bromopyridine-2-sulfonamide (CAS 65938-87-6)
- 3-(Nitromethyl)cyclopentanone (CAS 81266-47-9)
- (2-Cyclopropyltetrahydrofuran-2-yl)methanamine (CAS 1936679-50-3)
- 1-(2-(4-Methoxyphenyl)cyclopropyl)ethan-1-one (CAS 54064-36-7)
- Methyl 4-bromo-3-fluoro-2-hydroxybenzoate (CAS 1807191-62-3)
- (Des-Gly2)-Exenatide trifluoroacetate salt (CAS 1678416-78-8)
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