N-(3-chloro-2-methylphenyl)-N-(methylsulfonyl)glycine CAS 333320-75-5
| CAS No. | 333320-75-5 |
| Molecular Formula | C10H12ClNO4S |
| Molecular Weight | 277.72 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-(3-chloro-2-methylphenyl)-N-(methylsulfonyl)glycine.
N-(3-chloro-2-methylphenyl)-N-(methylsulfonyl)glycine (CAS 333320-75-5), molecular formula C10H12ClNO4S and molecular weight 277.72 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C10H12ClNO4S, N-(3-chloro-2-methylphenyl)-N-(methylsulfonyl)glycine contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 277.72 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H12ClNO4S |
| Molecular Weight | 277.72 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related N Standards
- Methyl 2-chloro-5-(dimethylsulfamoyl)benzoate (CAS 1031130-80-9)
- n-(2-Chloro-5-(methylsulfonyl)phenyl)-2-methoxyacetamide (CAS 1223534-37-9)
- Methyl 3-chloro-4-(N,N-dimethylsulfamoyl)benzoate (CAS 1263274-98-1)
- Ethyl 2-Chloro-6-(methylsulfonamido)benzoate (CAS 1447213-80-0)
- 2-Chloro-4-(morpholinosulfonyl)phenol (CAS 162711-35-5)
- [(5-Chloro-2-methyl-phenyl)-methanesulfonyl-amino]-acetic acid (CAS 362715-18-2)
- 2-Chloro-5-[(propan-2-yl)sulfamoyl]benzoic acid (CAS 74138-28-6)
- N-(3-chloro-4-methylphenyl)-N-(methylsulfonyl)glycine (CAS 392313-39-2)
Recommended Standards
- Methyl N-(4-chlorophenyl)-N-(methylsulfonyl)glycinate (CAS 363161-25-5)
- Methyl N-(3-chlorophenyl)-N-(methylsulfonyl)glycinate (CAS 503838-40-2)
- N-(4-chloro-2-methylphenyl)-N-(methylsulfonyl)glycine (CAS 425625-27-0)
- Methyl N-(2-chlorophenyl)-N-(methylsulfonyl)glycinate (CAS 392313-35-8)
- 2,6-Dimethylmorpholine-4-sulfonamide (CAS 4547-74-4)
- N-(But-2-enoyloxy)-2-(quinolin-8-yloxy)acetimidamide (CAS 88758-01-4)
- 2-((4-Amino-5-ethyl-4H-1,2,4-triazol-3-yl)thio)acetic acid (CAS 331837-70-8)
- Sildenafil EP Impurity G (CAS 1346602-67-2)
- Methyl N-(2,4-dichlorophenyl)-N-(phenylsulfonyl)glycinate (CAS 499979-78-1)
- Bupropion Impurity 48 (CAS 34841-35-5)
- 7-bromo-2,4-dichloro-1,8-naphthyridine (CAS 1824090-20-1)
- 5-methyl-1H-1,3-benzodiazole-2-carbaldehyde (CAS 883541-93-3)
- Tert-butyl octahydro-[1,4]oxazino[2,3-d]azepine-7(2H)-carboxylate (CAS 1822580-79-9)
- Insulin Lispro (CAS 133107-64-9)
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