Bupropion Impurity 48 CAS 34841-35-5
| CAS No. | 34841-35-5 |
| Molecular Formula | C9H9ClO |
| Molecular Weight | 168.62 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Bupropion Impurity 48 is closely related to a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Bupropion Impurity 48 (CAS 34841-35-5) is a certified pharmaceutical impurity reference standard with the molecular formula C9H9ClO and a molecular weight of 168.62 g/mol.
Bupropion Impurity 48 (C9H9ClO) contains a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H9ClO |
| Molecular Weight | 168.62 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Halogen Content | Cl-containing |
Related Bupropion Standards
- Bupropion Impurity 49 (CAS 535-80-8)
- Bupropion Impurity 17 (CAS 10557-17-2)
- Bupropion Impurity 46 (CAS 119802-69-6)
- Bupropion USP Related Compound C (CAS 152943-33-4)
- Bupropion USP Related Compound F (CAS 857233-13-7)
- Bupropion Impurity 13 (CAS 92821-92-6)
- Bupropion Impurity 32 (CAS CATO-C4X-120332)
- Bupropion Impurity 80 (CAS CATO-C4X-120380)
Recommended Standards
- 3-Chloropropiophenone (CAS 936-59-4)
- Flunarizine impurity 47 (CAS 2602342-57-2)
- 2-Phenylpropionyl chloride (CAS 22414-26-2)
- Methoxyphenamine impurity 6 (CAS 6305-95-9)
- Dequalinium impurity 24 (CAS CATO-C4X-193624)
- Alectinib Impurity 75 (CAS CATO-C4X-283675)
- Amlodipine Besylate EP Impurity A (CAS 88150-62-3)
- N-(prop-2-yn-1-yl)aniline (CAS 14465-74-8)
- 2,3-Diaminobutanoic acid (CAS 2643-66-5)
- (S)-1-(tert-butoxycarbonyl)-5,5-dimethylpyrrolidine-2-carboxylic acid (CAS 943318-67-0)
- n-(2-(Dibenzo[b,d]furan-2-yloxy)ethyl)acetamide (CAS 333353-51-8)
- Entacapone impurity 47 (CAS 1402714-31-1)
- 2883-45-6 Hepta-1,6-dien-4-ol 4-01-00-02249 (Beilstein Handbook Reference) AI3-37263 BRN 1736942 EINECS 220-742-0 NSC 97509 (CAS 2883-45-6)
- Liraglutide Impurity 20 TFA Salt (CAS CATO-C4X-199220)
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