Tert-butyl (2-(3,5-difluorophenyl)-2-hydroxyethyl)carbamate CAS 333388-01-5
| CAS No. | 333388-01-5 |
| Molecular Formula | C13H17F2NO3 |
| Molecular Weight | 273.28 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Tert-butyl (2-(3,5-difluorophenyl)-2-hydroxyethyl)carbamate (C13H17F2NO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Tert-butyl (2-(3,5-difluorophenyl)-2-hydroxyethyl)carbamate (CAS 333388-01-5), molecular formula C13H17F2NO3 and molecular weight 273.28 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Tert-butyl (2-(3,5-difluorophenyl)-2-hydroxyethyl)carbamate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H17F2NO3 |
| Molecular Weight | 273.28 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- Tert-butyl (2-(3,4-difluorophenyl)-2-hydroxyethyl)carbamate (CAS 218449-63-9)
- tert-Butyl (2,4-difluoro-3-(1-hydroxyethyl)phenyl)carbamate (CAS 2110320-47-1)
- Tert-butyl (2-(2,4-difluorophenyl)-2-hydroxyethyl)carbamate (CAS 939757-31-0)
- tert-Butyl 3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate (CAS 680185-88-0)
- 3,5,7,9,10-Pentachloro-2,2,3,4,4,5,6,6,7,8,8,9,10,10-tetradecafluorodecanoic acid (CAS 335-74-0)
- 2,3,4,6-Tetra-O-acetyl-aD-glucopyranose (CAS 6207-76-7)
- (4-((tert-Butoxycarbonyl)amino)bicyclo[2.2.2]octan-1-yl)methyl methanesulfonate (CAS 1333384-44-3)
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