Biotin impurity 01 CAS 33607-60-2
| CAS No. | 33607-60-2 |
| Molecular Formula | C24H28N2O3S |
| Molecular Weight | 424.56 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Biotin impurity 01 (CAS 33607-60-2, C24H28N2O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Biotin impurity 01 (C24H28N2O3S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C24H28N2O3S |
| Molecular Weight | 424.56 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Biotin Standards
- SLC-(+)-Biotin, 97% (CAS 1864003-57-5)
- Biotin EP Impurity A (CAS 1163708-46-0)
- Biotin-PEG4-OH (CAS 1217609-84-1)
- N-(Biotin)-N-bis(PEG1-alcohol) (CAS 2100306-75-8)
- Biotin-PEG3-Amine (CAS 359860-27-8)
- (+)-Biotin-PEG2-hydrazide (CAS 2413847-26-2)
- Biotin-PEG3-CH2COOH (CAS 1189560-96-0)
- Biotin-PEG3-oxyamine (CAS 1786206-22-1)
Recommended Standards
- (3aR,7aR)-1,3-Bis(2,4,6-trimethylbenzyl)octahydro-1H-benzo[d][1,3,2]diazaphosphole 2-oxide (CAS 2648048-91-1)
- 3-Cycloheptyl-6,7-dimethoxy-2-((pyridin-3-ylmethyl)thio)quinazolin-4(3H)-imine (CAS 691858-08-9)
- 1,4-Bis((2-(bis(methyl-d3)amino)ethyl)amino)-5,8-dihydroxyanthracene-9,10-dione (CAS 1562066-87-8)
- Methyl 2-((2-(allylthio)benzo[4,5]thieno[3,2-d]pyrimidin-4-yl)thio)benzoate (CAS 478030-03-4)
- Budesonide Impurity 80 (CAS CATO-C4X-138980)
- Bedaquiline impurity 41 (CAS 860720-24-7)
- Timolol Impurity 21 (CAS CATO-C4X-149621)
- N,N-di([1,1'-biphenyl]-4-yl)-9,9-diphenyl-9H-fluoren-4-amine (CAS 1547491-36-0)
- 3-[(3,5-difluorophenyl)methyl]piperidine (CAS 1225687-78-4)
- (2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone (CAS 871361-88-5)
- dimethyl(quinolin-2-ylmethyl)amine (CAS 776-93-2)
- N-(2-Fluorophenyl)-3-methylbenzofuran-2-carboxamide (CAS 325733-60-6)
- 3-(Trimethylsilyl)-2-propynal (CAS 2975-46-4)
- Liraglutide-d8 Tritrifluoroacetate (CAS CATO-C4X-199223)
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