Acetamide, N-(butoxymethyl)-2-chloro-N-[2-ethyl-6-(1-methylethyl)phenyl]- CAS 33717-34-9
| CAS No. | 33717-34-9 |
| Molecular Formula | C18H28ClNO2 |
| Molecular Weight | 325.87 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Acetamide, N-(butoxymethyl)-2-chloro-N-[2-ethyl-6-(1-methylethyl)phenyl]- is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Acetamide, N-(butoxymethyl)-2-chloro-N-[2-ethyl-6-(1-methylethyl)phenyl]- (CAS 33717-34-9), a pharmacopoeial impurity reference standard (molecular formula C18H28ClNO2, MW 325.87 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Acetamide, N-(butoxymethyl)-2-chloro-N-[2-ethyl-6-(1-methylethyl)phenyl]- (C18H28ClNO2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Acetamide, N-(butoxymethyl)-2-chloro-N-[2-ethyl-6-(1-methylethyl)phenyl]- under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H28ClNO2 |
| Molecular Weight | 325.87 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Acetamide Standards
- 61899-79-4 Acetamide, N-(2-(fluoromethyl)-3,4-dihydro-3-(2-methylphenyl)-4-oxo-6-quinazolinyl)- 5-25-15-00102 (Beilstein Handbook Reference) N-Acetylafloqualone BRN 0897461 N-(2-(Fluoromethyl)-3,4-dihydro-3-(2-methylphenyl)-4-oxo-6-quinazolinyl)acetamide (CAS 61899-79-4)
- Acetamide, N-(butoxymethyl)-2-chloro-N-[2-ethyl-6-(1-methylpropyl)phenyl]- (CAS 2834094-39-0)
- Acetamide, n-(4-bromo-1,1-dimethyl-3-oxobutyl)-2,2,2-trifluoro- (CAS 534620-39-8)
- Acetamide, 2,2,2-trifluoro-n-(2-imidazo[1,2-a]pyridin-2-yl-1,1-dimethylethyl)- (CAS 534620-40-1)
- 102387-48-4 Acetamide, N-(5-chloro-3-((4-(diethylamino)-2-methylphenyl)imino)-4-methyl-6-oxo-1,4-cyclohexadien-1-yl)- 2-Acetylamino-6-chloro-4-((4-diethylamino)-2-methylphenyl-imino)-5-methyl-1-oxo-2,5-cyclohexadiene N-(5-Chloro-3-(4-(diethylamino)-2-methylphenylimino)-4-methyl-6-oxo-1,4-cyclohexadienyl)acetamide EC 412-250-1 (CAS 102387-48-4)
- Acetamide, n-(3-bromo-2-methyl-6-nitrophenyl)- (CAS 861549-45-3)
- 65836-72-8 Acetamide, 2-chloro-N-((3,4-dimethoxyphenyl)methyl)- 3-13-00-02189 (Beilstein Handbook Reference) BRN 2857211 2-Chloro-N-((3,4-dimethoxyphenyl)methyl)acetamide N-(Dimethoxy-3,4 benzyl)-chloroacetamide [French] N-(Dimethoxy-3,4 benzyl)-chloroacetamide (CAS 65836-72-8)
- Acetamide, N,N-dimethyl-2-[[(3aR,5R,7aR)-octahydropyrano[3,2-b]pyrrol-5-yl]methoxy]-, rel- (CAS 1422140-63-3)
Recommended Standards
- Terbuchlor (CAS 4212-93-5)
- 3-(4-Chlorophenyl)-N-isopropyl-5-(methylthio)thiophene-2-carboxamide (CAS 477857-94-6)
- 2-{[(2-chloro-1,3-thiazol-5-yl)methyl]sulfanyl}-4-(thiophen-2-yl)pyrimidine (CAS 685107-87-3)
- N-(Butan-2-yl)-4-(5-chloro-2-methylphenyl)piperazine-1-carbothioamide (CAS 1048915-80-5)
- Rifambutin Nitrogen Oxide Open-ping impurity (CAS CATO-C4X-25125)
- Valaciclovir Hydrochloride EP Impurity F (CAS CATO-C4X-124858)
- Solifenacin EP Impurity A (CAS 118864-75-8)
- 1-(4-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)piperidin-1-yl)ethan-1-one (CAS 2135644-81-2)
- 5-Amino-1,4-dichloroanthracene-9,10-dione (CAS 3223-94-7)
- 3-Chloro-7-(trifluoromethyl)imidazo[1,2-a]pyridine (CAS 1956382-80-1)
- N1-(3-Fluoro-4-methylphenyl)-N2-(pyridin-3-ylmethyl)oxalamide (CAS 899956-51-5)
- 4-(2-Chloro-6-fluorophenyl)-1-methyl-1h-pyrazol-5-amine (CAS 1248079-27-7)
- Finasteride Impurity 13 (CAS CATO-C4X-164513)
- Semaglutide impurity 211 (CAS CATO-C4X-2226211)
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